Patents by Inventor Mauro Coluccia

Mauro Coluccia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL QUINOLINE DERIVATIVES AND USES THEREOF
    Publication number: 20250074880
    Abstract: The invention refers to new quinoline-4-carboxamide derivatives, pharmaceutical compositions containing thereof and the use of the same as inhibitors of Ndc80 kinetochore subcomplex-MIT binding and of kinetochore-MIT binding, more preferably for use in the treatment of cell proliferative disorders including cancers and drug-resistant cancer.
    Type: Application
    Filed: May 9, 2022
    Publication date: March 6, 2025
    Inventors: Saverio MINUCCI, Peter Arthur Irene DE WULF, Mauro ROMANENGHI, Riccardo CAZZOLI, Michela DAMIZIA, Romano SILVESTRI, Giuseppe LA REGINA, Antonio COLUCCIA
  • Method for synthesizing complexes of platinum with iminoethers and their use as antitumoral drugs and nucleotide-base modifiers
    Patent number: 6458983
    Abstract: A process for synthesizing complexes of platinum(II) with iminoethers having the formula: [PtIIX2(L)(L′)], where X is a monoanionic ligand, L is an iminoether ligand and L′ is an amine group or, exclusively for the case of cyclic iminoethers, a second iminoether ligand. The platinum(II) complexes according to the present invention are suitable for the production of medical remedies having a broad antitumoral spectrum. The complexes of platinum(II) with iminoethers according to the invention are furthermore suitable as agents for modifying nucleotide bases into antisense and/or antigene oligonucleotides.
    Type: Grant
    Filed: July 21, 1999
    Date of Patent: October 1, 2002
    Assignee: Universita' Degli Studi di Bari
    Inventors: Francesco Paolo Intini, Giovanni Natile, Angelina Boccarelli, Mauro Coluccia