Patents by Inventor Mauro DI PILATO

Mauro DI PILATO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MATERIALS AND METHODS OF TREATING CANCER
    Publication number: 20230235077
    Abstract: The present disclosure provides a method of treating cancer in a subject in need thereof comprising administering a checkpoint inhibitor to the subject, and administering a MALT-1 inhibitor according to an intermittent dosage regimen.
    Type: Application
    Filed: June 24, 2021
    Publication date: July 27, 2023
    Applicants: THE GENERAL HOSPITAL CORPORATION, MONOPTEROS THERAPEUTICS, INC.
    Inventors: Thorsten R. MEMPEL, Mauro DI PILATO, Ulrich H. VON ANDRIAN, Peter KELLER
  • Targeting the CBM signalosome complex induces regulatory T cells to inflame the tumor microenvironment
    Patent number: 11571427
    Abstract: Described herein are methods and compositions for the treatment of cancer. Aspects include administering (1) an agent that inhibits activity of a CBM signalosome complex, or (2) a cell engineered to have reduced CBM signalosome complex levels to a subject having cancer. In various embodiment, the methods further comprise administering second therapeutic, for example, a checkpoint inhibitor or anti-cancer therapy, to the subject.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 7, 2023
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Thorsten R. Mempel, Mauro Di Pilato
  • TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT
    Publication number: 20210052596
    Abstract: Described herein are methods and compositions for the treatment of cancer. Aspects include administering (1) an agent that inhibits activity of a CBM signalosome complex, or (2) a cell engineered to have reduced CBM signalosome complex levels to a subject having cancer. In various embodiment, the methods further comprise administering second therapeutic, for example, a checkpoint inhibitor or anti-cancer therapy, to the subject.
    Type: Application
    Filed: December 28, 2018
    Publication date: February 25, 2021
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Thorsten R. MEMPEL, Mauro DI PILATO