Patents by Inventor Mauro Ercoli

Mauro Ercoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHENYLTETRAZOLE COMPOUNDS
    Publication number: 20080119657
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Application
    Filed: January 29, 2008
    Publication date: May 22, 2008
    Applicant: DIPHARMA S. P. A.
    Inventors: Gabriele RAZZETTI, Domenico Magrone, Mauro Ercoli
  • Phenyltetrazole compounds
    Patent number: 7345072
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: March 18, 2008
    Assignee: Dipharma S.p.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli
  • Process for the preparation of adapalene
    Patent number: 7345189
    Abstract: A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: March 18, 2008
    Assignees: Dipharma S.p.A., Lundbeck Pharmaceuticals, Italy
    Inventors: Graziano Castaldi, Pietro Allegrini, Gabriele Razzetti, Mauro Ercoli
  • Process for the preparation of adapalene
    Publication number: 20060229465
    Abstract: A process for the preparation of a compound of formula (I), or a salt thereof wherein R is H, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; comprising the reaction between a compound of formula (II) wherein R1 and R2 are independently hydrogen, C1-C8 alkyl, aryl, aryl-C1-C8 alkyl, or R1 and R2, taken together, form a —(CH2)m—V—(CH2)n— group, in which V is NR3 or C(R3)2 wherein R3 is hydrogen, C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; and m and n, which can be the same or different, are 1 or 2; with a compound of formula (III) in which R4 and R5 are independently C1-C8 alkyl, aryl or aryl-C1-C8 alkyl; in the presence of a Ni (II) salt, an organic ligand and a basic agent, to obtain a compound of formula (I) wherein R is C1-C8 alkyl, aryl or aryl-C1-C8 alkyl and, if desired, its conversion to a compound of formula (I) wherein R is hydrogen or to a salt thereof.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 12, 2006
    Inventors: Graziano Castaldi, Pietro Allegrini, Gabriele Razzetti, Mauro Ercoli
  • Process for the preparation of crystalline losartan potassium
    Publication number: 20050131040
    Abstract: A process for the preparation of crystalline losartan potassium and crystalline hydrate losartan potassium.
    Type: Application
    Filed: December 14, 2004
    Publication date: June 16, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli, Pietro Allegrini, Graziano Castaldi
  • Phenyltetrazole compounds
    Publication number: 20050119488
    Abstract: Novel phenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists and the processes for the conversion thereof to biologically active molecules.
    Type: Application
    Filed: November 24, 2004
    Publication date: June 2, 2005
    Applicant: DIPHARMA S.P.A.
    Inventors: Gabriele Razzetti, Domenico Magrone, Mauro Ercoli