Abstract: A lantibiotic solution against bacterial infections comprises an aqueous solvent, a water-soluble polymeric component, class I bacteriocins, and amphipathic molecules.

Abstract: A controlled-viscosity polymeric hydrogel including an aqueous solvent, a water-soluble synthetic polymeric component and an anti-cross-linking component, constituted of a polyphenol, in particular of hydroxytyrosol.

Abstract: A method of making a hydrogel for use as carrier and/or substitute of connective tissues includes providing an aqueous solution, adding and solubilizing a first electromagnetic radiation-polymerizable water-soluble polymer a polymerization regulator agent, for regulating the polymerization of the first polymer, and applying an electromagnetic radiation to achieve polymerization of the first polymer with a predetermined viscosity and obtain a sterile hydrogel. A second radiation-polymerizable water-soluble polymer, different from the first and is non-reactive to the regulator, is added before application of the electromagnetic radiation, the amounts of regulator agent, first polymer and second polymer being selected to control the final consistency and viscosity of the sterile hydrogel. The second polymer has a degree of polymerization that varies according to the intermolecular steric hindrance of the chains of the first polymer.

Abstract: A device for perfusing porous biomaterials with biological liquids includes a tubular body with an axial cavity defining a perfusion chamber for containing a porous biocompatible material, a connector at a distal end of the tubular body for receiving a perfusion liquid, a plunger having a distal end slidably movable in the cavity to withdraw air from the biomaterial, a vent for releasing the air withdrawn from the biomaterial and contained in the chamber, and a filter permitting selective passage of the air contained in the chamber toward the vent, while preventing leakage of the liquid to the outside. An air collector communicates with the chamber and the vent, and a control unit is associated with the plunger and designed to be actuated by the user to control the air flow from the air collector to the vent. A method of perfusing porous biomaterials with biological liquids.

Abstract: A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3).

Abstract: A method for perfusing a biocompatible material graft with a perfusion liquid includes the steps of: introducing the graft (100) in a perfusion chamber (2), arranging a transfer chamber (3) partly filled with the perfusion liquid (101), coupling in a tight manner the perfusion chamber (2) and the transfer chamber (3) for establishing a fluid communication between them, lowering the pressure in the transfer chamber (3) for transferring therein part of the air existing in the perfusion chamber (2), increasing the pressure within the transfer chamber (3) for injecting in the perfusion chamber (2) the perfusion liquid (101) existing in the transfer chamber (3).