Patents by Inventor Mauro Gobbini

Mauro Gobbini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diterpenoid derivatives endowed of biological properties
    Patent number: 8822692
    Abstract: The present invention relates to new diterpenoid derivatives of formula (I), processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, urinary incontinence, asthma, or Alzheimer's disease and/or to prevent obstructive vascular lesions consequently to arteriotomy and/or angioplasty, and to prevent organ damage in hypertensive patients.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: September 2, 2014
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite, S.p.A.
    Inventors: Alberto Cerri, Mauro Gobbini, Marco Torri, Patrizia Ferrari, Mara Ferrandi, Giuseppe Bianchi
  • Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
    Patent number: 8664210
    Abstract: New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: March 4, 2014
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Giuseppe Bianchi, Giorgio Fedrizzi, Patrizia Ferrari, Mauro Gobbini, Marco Torri, Giuseppe Marazzi, Walter Cabri
  • DITERPENOID DERIVATIVES ENDOWED OF BIOLOGICAL PROPERTIES
    Publication number: 20130310423
    Abstract: The present invention relates to new diterpenoid derivatives of formula (I), processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, urinary incontinence, asthma, or Alzheimer's disease and/or to prevent obstructive vascular lesions consequently to arteriotomy and/or angioplasty, and to prevent organ damage in hypertensive patients.
    Type: Application
    Filed: July 26, 2013
    Publication date: November 21, 2013
    Applicant: SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Mauro Gobbini, Marco Torri, Patrizia Ferrari, Mara Ferrandi, Giuseppe Bianchi
  • Azaheterocyclyl derivatives of androstanes and androstenes as medicaments for cardiovascular disorders
    Patent number: 8536160
    Abstract: Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: September 17, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Alberto Cerri, Giorgio Fedrizzi, Alessandra Benicchio, Giuseppe Bianchi, Patrizia Ferrari, Mauro Gobbini, Rosamaria Micheletti, Marco Pozzi, Piero Enrico Scotti
  • AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS
    Publication number: 20100324003
    Abstract: New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
    Type: Application
    Filed: September 18, 2008
    Publication date: December 23, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Alberto Cerri, Giuseppe Bianchi, Giorgio Fedrizzi, Patrizia Ferrari, Mauro Gobbini, Giuseppe Marazzi, Marco Torri, Walter Cabri
  • AZAHETEROCYCLYL DERIVATIVES OF ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS
    Publication number: 20090275542
    Abstract: Compounds of formula (I) wherein: the groups are as defined in the description, are useful for the preparation of medicaments for the treatment of cardiovascular disorders, in particular heart failure and hypertension. The compounds are inhibitors of the enzymatic activity of the Na+, K+-ATPase. They are useful for the preparation of a medicament for the treatment of a disease caused by the hypertensive effects of endogenous ouabain, such as renal failure progression in autosomal dominant polycystic renal disease (ADPKD), preeclamptic hypertension and proteinuria and renal failure progression in patients with adducin polymorphisms.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 5, 2009
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
    Inventors: Alberto Cerri, Giorgio Fedrizzi, Alessandra Benicchio, Giuseppe Bianchi, Patrizia Ferrari, Mauro Gobbini, Rosamaria Micheletti, Marco Pozzi, Piero Enrico Scotti
  • Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6, 17-dione and its analogues
    Patent number: 6384250
    Abstract: An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n=1 and R1=R2=H
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 7, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Giulio Carzana, Simona Sputore
  • Process for the preparation of (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione and its analogues
    Publication number: 20010056182
    Abstract: An improved process is described for the preparation of compounds with general formula (I) and particularly for the preparation of the compound (E,Z) 3-(2-aminoethoxyimino)-androstane-6,17-dione, in which n=1 and R1=R2=H.
    Type: Application
    Filed: May 10, 2001
    Publication date: December 27, 2001
    Inventors: Mauro Gobbini, Giulio Carzana, Simona Sputore
  • Seco-d steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
    Patent number: 5955632
    Abstract: New seco-D steroid derivatives, processes for their preparation and pharmaceutical compositions are provided, which are active on the cardiovascular system.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: September 21, 1999
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Sergio De Munari, Giorgio Fedrizzi, Patrizia Ferrari, Piero Melloni, Marco Santagostino, Marco Torri
  • Seco-D steroids active on the cardiovascular system and pharmaceutical compositions containing same
    Patent number: 5731345
    Abstract: Seco-D steroid derivatives having the formula ##STR1## wherein R, R.sup.1, R.sup.2 and R.sup.3 have the meanings specified in the specification, useful as cardiovascular agents and pharmaceutical compositions containing same, are disclosed.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: March 24, 1998
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A
    Inventors: Mauro Gobbini, Patrizia Ferrari, Piero Melloni, Marco Torri
  • Process for the preparation of 3 .beta., 14 .beta.-dihydroxyethianaldehyde
    Patent number: 5596110
    Abstract: An improvement in a process for producing 3.beta.,14.beta.-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO.sub.2 hydrate or RuCl.sub.3 with the alkaline periodate.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: January 21, 1997
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Marco Torri
  • Cyclopentanperhydrophenanthren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
    Patent number: 5593982
    Abstract: Cyclopentanperhydrophenantren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension, are disclosed.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: January 14, 1997
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Luisa Quadri, Luigi Bernardi, Patrizia Ferrari, Mauro Gobbini, Piero Melloni, Loredana Valentino
  • Cyclopentanperhydrophenanthren-17.beta.-(hydroxy or alkoxy)-17.alpha.-(Aryl or heterocyclyl)-3.beta.-derivatives active on the cardiovascular system, and pharmaceutical compositions containing same
    Patent number: 5521167
    Abstract: The present invention relates to new cyclopentanperhydrophenanthren-17-(hydroxy or alkoxy)-17-(aryl or heterocyclyl)-3.beta.-derivatives, active on the cardiovascular system, to a process for their preparation and to pharmaceutical compositions containing them. The invention relates to compounds of general formula (I) ##STR1## wherein X is O or S and R, R.sup.1 and R.sup.2 is selected from various groups.
    Type: Grant
    Filed: September 29, 1993
    Date of Patent: May 28, 1996
    Assignee: Sigma-Tau Industrie Farmceutiche Riunite S.p.A.
    Inventors: Mauro Gobbini, Mara Ferrandi, Marco Frigerio, Piero Melloni, Marco Torri, Loredana Valentino
  • 14-deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical composition comprising same for treating cardiovascular disorders
    Patent number: 5489582
    Abstract: 14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.
    Type: Grant
    Filed: June 24, 1993
    Date of Patent: February 6, 1996
    Assignee: Sigma-Tau Industrie Farmaceutiche Riuntie S.p.A
    Inventors: Mauro Gobbini, Luigi Bernardi, Mara Ferrandi, Piero Melloni, Luisa Quadri, Roberto Villa
  • Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
    Patent number: 5478817
    Abstract: Digitoxigenin and dihydrodigitoxigenin 3.beta.-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: December 26, 1995
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Piero Melloni, Luigi Bernardi, Patrizia Ferrari, Mauro Gobbini, Marco Torri, Loredana Valentino
  • Cyclopentanperhydrophenanthren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders
    Patent number: 5432169
    Abstract: Cyclopentanperhydrophenantren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension, are disclosed.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: July 11, 1995
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Luisa Quadri, Luigi Bernardi, Patrizia Ferrari, Mauro Gobbini, Piero Melloni, Loredana Valentino
  • t-alkyl ergoline derivatives
    Patent number: 5079364
    Abstract: t-alkyl eroline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinynoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts.A process for the preparation of these derivatives from lysergol and a t-alkyl alcohol is also described, as are pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 24, 1989
    Date of Patent: January 7, 1992
    Assignee: Farmitalia Carlo Erba
    Inventors: Aldemio Temperilli, Enzo Brambilla, Mauro Gobbini, Maria A. Cervini
  • Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositions containing them
    Patent number: 4920099
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: April 24, 1990
    Assignee: Farmitalie Carlo Erba S.p.A.
    Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniela Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari
  • Nor-cholanic acid derivatives, a process for their preparation, their use and pharmaceutical compositions containing them
    Patent number: 4895836
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: January 23, 1990
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari
  • Aminoglycoside steroids, a process for their preparation, their use and pharmaceutical compositions containing them
    Patent number: 4882315
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: November 21, 1989
    Assignee: Farmitalia Carlo Erba S.p.A.
    Inventors: Laura Chiodini, Mauro Gobbini, Sergio Mantegani, Daniel Ruggieri, Aldemio Temperilli, Gabriella Traquandi, Patrizia Ferrari