Abstract: The present invention relates to humanised antibody molecules having specificity for ?-1,3 glucans and compositions comprising the same. The present invention also relates to the therapeutic uses of the antibody molecules, wherein said use is in the treatment or prophylaxis of fungal infections. It is further claimed a synergistic combination of a) at least one humanised antibody which has specificity for ?-1,3 glucans and b) one or more antifungal agents for use in the treatment or prophylaxis of infections of human cells.

Abstract: The present invention relates to a novel procedure for evaluating the response of patients affected by Ataxia Talangiectasia (A-T) to glucocorticoids treatment. In particular, the procedure provides a step of qualitative and/or quantitative identification in the blood of said patients of the expression of a mRNA variant of the ATM (Ataxia-Talangiectasia-Mutated) gene produced by non-canonical splicing induced by glucocorticoid (GC). In fact, it was demonstrated that mRNA variant expression is present in the blood of patients who responded positively to treatment with GC.

Abstract: The present invention relates to a novel procedure for evaluating the response of patients affected by Ataxia Talangiectasia (A-T) to glucocorticoids treatment. In particular, the procedure provides a step of qualitative and/or quantitative identification in the blood of said patients of the expression of a mRNA variant of the ATM (Ataxia-Talangiectasia-Mutated) gene produced by non-canonical splicing induced by glucocorticoid (GC). In fact, it was demonstrated that mRNA variant expression is present in the blood of patients who responded positively to treatment with GC.

Abstract: Erythrocytes exposed to dialysis with an hypotonic buffer stably take up superparamagnetic iron oxide nanoparticles and may be used MRI contrast agents. Such erythrocytes may also be used as drug delivery vehicles.

Abstract: Tat protein produced in bulk culture is inactive when induced at conventional optical densities but can be obtained in biologically active form when induced during the logarithmic growth phase.

Abstract: The present invention concerns a device and a method of single-molecule analysis by detection of a target molecule on functionalized nanopores in such a way that it interacts with the target molecule and has an effective diameter smaller than the dimension of the target molecule.

Abstract: Red blood cells can be used as effective drug delivery systems when they contain proteins that do not readily diffuse out and which form affinity complexes with the desired drug.

Abstract: Glutathione derivatives (GSH) of formula I are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.

Abstract: Red blood cells can be used as effective drug delivery systems when they contain proteins that do not readily diffuse out and which form affinity complexes with the desired drug.

Abstract: Tat protein produced in bulk culture is inactive when induced at conventional optical densities but can be obtained in biologically active form when induced during the logarithmic growth phase.

Abstract: Erythrocytes exposed to dialysis with an hypotonic buffer stably take up superparamagnetic iron oxide nanoparticles and may be used MRI contrast agents. Such erythrocytes may also be used as drug delivery vehicles.

Abstract: Use of the tetramerous derivative of indole-3-carbinol having formula I for preparing a medicinal having anti-carcinogenic activity, and method of synthesis of the tetramerous derivative having formula I, in which indole-3-carbinol is reacted with an oxidizing agent so as to cause a polymeric oxidation of indole-3-carbinol.

Abstract: Glutathione derivatives (GSH) of formula (I) are provided, wherein R is a thiol protection group. The derivatives are useful for the treatment of infections from Paramyxovirus, Orthomyxovirus, Herpes Simplex Virus and Acquired Immunodeficiency Syndrome Virus.

Abstract: Use of the tetramerous derivative of indole-3-carbinol having formula I 1

Abstract: A panoramic telescope of the type having a body 3 to be mounted on a vehicle, a head-piece 9 attached to the body and rotating with respect thereto. A window 11 is provided for observing the external scenery. Inside the head-piece is a mirror 13 for deflecting the incoming beam from the window towards an optical detector.

Abstract: A panoramic periscope includes a central body (3, 3A) and a rotating head-piece (9) supported on the central body. Inside the central body, an optical path (21, 23, 101, 105, 109, 111, 113) for an optical beam (F,) coming from the head-piece (9) is provided. A viewing module (17) receives the optical beam, for observing the external scenery. A laser telemeter (19) is provided and, along the optical path, a separator element (10S) with an inner dichroic surface (105A) is passed through by the optical beam coming from the head-piece (9). The inner dichroic surface (105A) separates a laser beam coming from the head-piece (9) and deviating it towards a separate optical path (107) which conveys the laser beam towards the laser telemeter (19). The separator element (105) has an entry surface (105I) and an exit surface (105U) which are parallel with one another and passed through by the optical beam (FV), the surfaces being perpendicular to the optical beam (FV).

Abstract: An infrared image sensor, in particular one of the interlaced parallel scanning type, is described. The infrared image sensor has an optical focusing system for focusing an image on a matrix of sensitive elements (55) for the detection of the image. A collimator unit (5) forms a focal plane. The collimator unit is disposed at the entry of the sensor. At least one thermal reference (33), whose image is projected on the matrix (55), is disposed on the optical path of the image inside the sensor.

Abstract: A method and apparatus for the encapsulation of biologically active agents in red blood cells (RBCS) is disclosed. The method is characterized in that lysed and partially lysed RBCs are concentrated prior to the introduction of the biologically active agent. The resultant carrier RBCs are stable for an extended period of time under physiological conditions and can be used for the systemic or targeted delivery of therapeutically effective amounts of one or more biologically active agents to a patient.

Abstract: A panoramic telescope of the type having a body 3 to be mounted on a vehicle, a head-piece 9 attached to the body and rotating with respect thereto. A window 11 is provided for observing the external scenery. Inside the head-piece is a mirror 13 for deflecting the incoming beam from the window towards an optical detector.

Abstract: The invention relates to compositions of erythrocytes that have been modified following hypotonic lysis and resealing by addition of 2',3'-dideoxycytidine-5'-triphosphate (ddCTP) or 3'-azido-3'-deoxythymidine-5'-triphosphate (AZT-TP). These compositions may also contain ATP. Also disclosed are methods of preparing these compositions.