Patents by Inventor Mauro Napoletano

Mauro Napoletano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRPV1 vanilloid receptor antagonists with a bicyclic portion
    Patent number: 10233177
    Abstract: The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: March 19, 2019
    Inventors: Mauro Napoletano, Marcello Trevisani, Maria Giovanna Pavani, Francesca Fruttarolo
  • TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion
    Publication number: 20170152252
    Abstract: The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1.
    Type: Application
    Filed: February 13, 2017
    Publication date: June 1, 2017
    Inventors: Mauro Napoletano, Marcello Trevisani, Maria Giovanna Pavani, Francesca Fruttarolo
  • TRPV1 Vanilloid Receptor Antagonists With A Bicyclic Portion
    Publication number: 20160289199
    Abstract: The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1.
    Type: Application
    Filed: December 21, 2015
    Publication date: October 6, 2016
    Inventors: Mauro Napoletano, Marcello Trevisani, Maria Giovanna Pavani, Francesca Fruttarolo
  • Sulfonamide TRPA1 receptor antagonists
    Patent number: 9409864
    Abstract: The invention discloses compounds of Formula (I). The compounds of formula (I) are TRPA1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of TRPA1 receptors.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: August 9, 2016
    Assignee: ARIO PHARMA LIMITED
    Inventors: Francesca Fruttarolo, Maria Giovanna Pavani, Serena Bencivenni, Raffaele Gatti, Mauro Napoletano
  • Novel Sulfonamide TRPA1 Receptor Antagonists
    Publication number: 20160024009
    Abstract: The invention discloses compounds of Formula (I). The compounds of formula (I) are TRPA1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of TRPA1 receptors.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 28, 2016
    Applicant: ARIO PHARMA LIMITED
    Inventors: Francesca Fruttarolo, Maria Giovanna Pavani, Serena Bencivenni, Raffaele Gatti, Mauro Napoletano
  • TRPV1 vanilloid receptor antagonists with a bicyclic portion
    Patent number: 9216975
    Abstract: The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: December 22, 2015
    Assignee: Serentrix, LLC.
    Inventors: Mauro Napoletano, Marcello Trevisani, Maria Giovanna Pavani, Francesca Fruttarolo
  • 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
    Patent number: 8470877
    Abstract: 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: June 25, 2013
    Assignee: Newron Pharmaceuticals S.p.A.
    Inventors: Florian Thaler, Mauro Napoletano, Cibele Sabido-David, Ermanno Moriggi, Carla Caccia, Laura Faravelli, Alessandra Restivo, Patricia Salvati
  • TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION
    Publication number: 20130079339
    Abstract: The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1.
    Type: Application
    Filed: December 22, 2010
    Publication date: March 28, 2013
    Applicant: PHARMESTE S.R.L.
    Inventors: Mauro Napoletano, Marcello Trevisani, Maria Giovanna Pavani, Francesca Fruttarolo
  • 2-PHENYLETHYLAMINO DERIVATIVES AS CALCIUM AND/OR SODIUM CHANNEL MODULATORS
    Publication number: 20120220592
    Abstract: 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.
    Type: Application
    Filed: January 26, 2012
    Publication date: August 30, 2012
    Applicant: Newron Pharmaceuticals S.p.A.
    Inventors: Florian THALER, Mauro NAPOLETANO, Cibele SABIDO-DAVID, Ermanno MORIGGI, Carla CACCIA, Laura FARAVELLI, Alessandra RESTIVO, Patricia SALVATI
  • 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
    Patent number: 8129427
    Abstract: 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: March 6, 2012
    Assignee: Newron Pharmaceuticals S.p.A.
    Inventors: Florian Thaler, Mauro Napoletano, Cibele Sabido-David, Ermanno Moriggi, Carla Caccia, Laura Faravelli, Alessandra Restivo, Patricia Salvati
  • Crystalline forms of macrolide compounds endowed with antiinflammatory activity
    Patent number: 7956042
    Abstract: The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Grant
    Filed: July 5, 2006
    Date of Patent: June 7, 2011
    Assignee: Zambon S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini
  • 2-Phenylethylamino Derivatives as Calcium and/or Sodium Channel Modulators
    Publication number: 20110046129
    Abstract: 2-Phenylethylamino substituted carboxamide derivatives and their use as sodium and/or calcium channel modulators useful in preventing, alleviating and curing a wide range of pathologies are presented.
    Type: Application
    Filed: September 9, 2010
    Publication date: February 24, 2011
    Applicant: Newron Pharmaceuticals S.p.A.
    Inventors: Florian Thaler, Mauro Napoletano, Cibele Sabido-David, Ermanno Moriggi, Carla Caccia, Laura Faravelli, Alessandra Restivo, Patricia Salvati
  • 2-phenylethylamino derivatives as calcium and/or sodium channel modulators
    Patent number: 7855227
    Abstract: 2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R0, R1, R2, R3, and R4 have the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: December 21, 2010
    Assignee: Newron Pharmaceuticals S.p.A.
    Inventors: Florian Thaler, Mauro Napoletano, Cibele Sabido-David, Ermanno Moriggi, Carla Caccia, Laura Faravelli, Alessandra Restivo, Patricia Salvati
  • Isoxazolic derivative to relieve neuropathic pain
    Patent number: 7834040
    Abstract: The present invention relates to new pharmaceutical uses of an isoxazolic derivative or a pharmaceutically acceptable salt thereof in the preparation of a medicament useful for treating the neuropathic pain.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: November 16, 2010
    Assignee: Zambon S.p.A.
    Inventors: Mauro Napoletano, Ermanno Moriggi
  • Macrolide compounds endowed with antiinflammatory activity
    Patent number: 7704960
    Abstract: Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them as active ingredient.
    Type: Grant
    Filed: October 28, 2008
    Date of Patent: April 27, 2010
    Assignee: Zambon Group S.p.A.
    Inventors: Mauro Napoletano, Ermanno Moriggi, Andrea Mereu, Fernando Ornaghi, Gabriele Morazzoni, Roberto Longoni, Carlo Riva, Luciano Pacchetti, Franco Pellacini
  • MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY
    Publication number: 20100099634
    Abstract: The present invention relates to macrolide derivatives of formula (I) in which R1 and R2 have the meanings given in the description; which are endowed with antiinflammatory activity and are substantially free of antibiotic properties, to pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing them as active ingredient.
    Type: Application
    Filed: December 12, 2006
    Publication date: April 22, 2010
    Applicant: Zambon S.p.A
    Inventors: Andrea Mereu, Ermanno Moriggi, Mauro Napoletano, Franco Pellacini
  • Macrolides with antiinflammatory activity
    Patent number: 7507721
    Abstract: Macrolide compounds of formula (I) wherein X, R, R1, R2, R3 and R4, have the meanings as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and the use thereof in the treatment and prophylaxis of inflammatory diseases, are described.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: March 24, 2009
    Assignee: Zambon Group S.p.A.
    Inventors: Andrea Mereu, Mauro Napoletano, Fernando Ornaghi, Ermanno Moriggi, Franco Pellacini
  • MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY
    Publication number: 20090054357
    Abstract: Macrolide compounds endowed with antiinflammatory activity are described, and more particularly macrolide derivatives lacking cladinose in position 3, with antiinflammatory activity, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing them as active ingredient.
    Type: Application
    Filed: October 28, 2008
    Publication date: February 26, 2009
    Applicant: ZAMBON GROUP S.P.A.
    Inventors: Mauro NAPOLETANO, Ermanno Moriggi, Andrea Mereu, Fernando Ornaghi, Gabriele Morazzoni, Roberto Longoni, Carlo Riva, Luciano Pacchetti, Franco Pellacini
  • Macrolide compounds endowed with antiinflammatory activity
    Patent number: 7488811
    Abstract: Macrolide compounds lacking cladinose in position 3 having antiinflammatory activity and substantially free of antibiotic properties, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them as active ingredient.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: February 10, 2009
    Assignee: Zambon Group S.p.A.
    Inventors: Mauro Napoletano, Ermanno Moriggi, Andrea Mereu, Fernando Ornaghi, Gabriele Morazzoni, Roberto Longoni, Carlo Riva, Luciano Pacchetti, Franco Pellacini
  • CRYSTALLINE FORMS OF MACROLIDE COMPOUNDS ENDOWED WITH ANTIINFLAMMATORY ACTIVITY
    Publication number: 20090018089
    Abstract: the present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.
    Type: Application
    Filed: July 5, 2006
    Publication date: January 15, 2009
    Applicant: ZAMBON S.p.A.
    Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini