Patents by Inventor Mauro Perseghini

Mauro Perseghini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl)urea, methods of preparation, and uses thereof
    Patent number: 11884646
    Abstract: Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.
    Type: Grant
    Filed: March 7, 2022
    Date of Patent: January 30, 2024
    Assignee: HELSINN HEALTHCARE SA
    Inventors: Silvina Garcia Rubio, Mauro Perseghini, Angelo Guainazzi, Claudio Pietra, Claudio Giuliano
  • Fumarate Salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl)urea, Methods of Preparation, and Uses Thereof
    Publication number: 20220340541
    Abstract: Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.
    Type: Application
    Filed: March 7, 2022
    Publication date: October 27, 2022
    Applicant: Helsinn Healthcare SA
    Inventors: Silvina Garcia Rubio, Mauro Perseghini, Angelo Guainazzi, Claudio Pietra, Claudio Giuliano
  • Fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2- trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, methods of preparation, and uses thereof
    Patent number: 11299472
    Abstract: Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: April 12, 2022
    Assignee: HELSINN HEALTHCARE SA
    Inventors: Silvina Garcia Rubio, Mauro Perseghini, Angelo Guainazzi, Claudio Pietra, Claudio Giuliano
  • Fumarate Salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl) urea, Methods of Preparation, and Uses Thereof
    Publication number: 20200299260
    Abstract: Provided are various embodiments relating to fumarate salt of (R)-3-(1-(2,3-dichloro-4-(pyrazin-2-yl)phenyl)-2,2,2-trifluoroethyl)-1-methyl-1-(1-methylpiperidin-4-yl)urea, and methods of producing and using the same to treat conditions and disorders associated with an increase of ghrelin level, such as food abuse, alcohol addiction, and other disorders (e.g., Prader-Willi syndrome). Also provided are various embodiments relating to crystalline HM04 free base, different crystalline forms of HM04 fumarate salt, and methods of producing the same.
    Type: Application
    Filed: December 7, 2018
    Publication date: September 24, 2020
    Applicant: Helsinn Healthcare SA
    Inventors: Silvina GARCIA RUBIO, Mauro PERSEGHINI, Angelo GUAINAZZI, Claudio PIETRA, Claudio GIULIANO
  • Continuous process for the alkylation of cyclic tertiary amines
    Patent number: 8865903
    Abstract: A continuous process for the alkylation of tertiary amines and, in particular, to a continuous process for the quaternization of cyclic tertiary amines useful for the preparation of cyclic quaternary ammonium salts with high purity is described.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: October 21, 2014
    Assignee: Cerbios-Pharma SA
    Inventors: Andrea Mereu, Moreno Morosoli, Mauro Perseghini, Alessandro Spreafico
  • CRYSTALLINE FORM OF TIOTROPIUM BROMIDE
    Publication number: 20140303373
    Abstract: A stable crystalline form of tiotropium bromide, and a process for its preparation with high purity.
    Type: Application
    Filed: February 25, 2014
    Publication date: October 9, 2014
    Applicant: CERBIOS-PHARMA SA
    Inventors: Andrea MEREU, Moreno MOROSOLI, Umberto PENNE', Mauro PERSEGHINI
  • Asymmetric Catalytic Hydrogenation of Prochiral Ketones and Aldehydes
    Publication number: 20090105481
    Abstract: Process for stereoselective hydrogenation by reacting racemic aldehydes or ketones having a stereogenic carbon atom in the position relative to the C(O) group and containing the structural element —(O)C—C—CH— by means of hydrogen in the presence of a base and a ruthenium complex containing a bidentate ligand having coordinating P and N atoms, a monophosphine ligand and anionic and/or uncharged ligands as homogeneous catalyst, with the charge being balanced by one or two monovalent acid anions or a divalent acid anion when uncharged ligands are present.
    Type: Application
    Filed: March 8, 2007
    Publication date: April 23, 2009
    Inventors: Felix Spindler, Ulrike Nettekoven, Mauro Perseghini