Patents by Inventor Maury D. Cosman
Maury D. Cosman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220381765Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: ApplicationFiled: June 13, 2022Publication date: December 1, 2022Inventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Patent number: 11360074Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: GrantFiled: May 27, 2020Date of Patent: June 14, 2022Assignee: Coagulation Sciences LLCInventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Publication number: 20200292524Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: ApplicationFiled: May 27, 2020Publication date: September 17, 2020Inventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Patent number: 10705072Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: GrantFiled: November 22, 2019Date of Patent: July 7, 2020Assignee: Coagulation Sciences LLCInventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Patent number: 10520489Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: GrantFiled: September 12, 2019Date of Patent: December 31, 2019Assignee: Coagulation Sciences LLCInventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Patent number: 10429377Abstract: A coagulation test device for measuring clotting time and clot characteristics of a whole blood sample under different hemostatic conditions. Results of the test are used as an aid in management of patients with coagulopathy of unknown etiology in order to help the physician determine appropriate clinical action to arrest bleeding in a patient.Type: GrantFiled: March 15, 2019Date of Patent: October 1, 2019Assignee: COAGULATION SCIENCES LLCInventors: Sheldon Goldstein, Michael Kagan, Nicholas Lauder, Maury D. Cosman
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Publication number: 20190255205Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.Type: ApplicationFiled: May 6, 2019Publication date: August 22, 2019Inventors: Maury D. Cosman, Bruce L. Carvalho
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Patent number: 10335508Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.Type: GrantFiled: January 29, 2018Date of Patent: July 2, 2019Assignee: LivOnyx Inc.Inventors: Maury D. Cosman, Bruce L. Carvalho
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Publication number: 20180161467Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.Type: ApplicationFiled: January 29, 2018Publication date: June 14, 2018Inventors: Maury D. Cosman, Bruce L. Carvalho
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Patent number: 9919069Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.Type: GrantFiled: May 23, 2016Date of Patent: March 20, 2018Assignee: LivOnyx Inc.Inventors: Maury D. Cosman, Bruce L. Carvalho
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Publication number: 20160339132Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.Type: ApplicationFiled: May 23, 2016Publication date: November 24, 2016Inventors: Maury D. Cosman, Bruce L. Carvalho
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Publication number: 20120292804Abstract: This invention relates to an apparatus and methods for forming polymeric devices, especially fluidic or microfluidic devices used as conduits for controlling fluid flow. Such devices have important applications in chemistry and biology including immunoassays, enzyme assays and cell separation processes. The invention claims the use of fixed-temperature heating of thermoplastic resin in combination with vacuum and low pressure on the tool in order to rapidly produce good quality devices. The combination of features claimed in the invention is important because it enables simple, lightweight, economical equipment to be constructed to fabricate useful polymeric devices.Type: ApplicationFiled: March 26, 2012Publication date: November 22, 2012Inventors: Bruce L. Carvalho, Maury D. Cosman
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Patent number: 7348176Abstract: The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates sandwiching a compressible gasket and a substantially incompressible stop can be adjusted using a gasket that forms a fluid-tight seal between the plates at a plurality of levels of compression. The invention enables the culture of cells between substantially parallel and rigid plates in which a relatively large volume can be used to seed the cells and the holdup volume reduced for perfusion without opening or otherwise disassembling the system to compromise its liquidtightness and sterility. The new closed, modular and scalable cell-culturing chamber can be thus perfused and used to culture cells (e.g., hepatocytes) with high levels of cell function in organ (e.g.Type: GrantFiled: February 14, 2005Date of Patent: March 25, 2008Assignee: Organogenesis, Inc.Inventors: Paul A. DiMilla, Maury D. Cosman, Rachel Halych, Lisa Romito, Chris Gemmeti, Kevin Odlum
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Patent number: 6978815Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: GrantFiled: December 19, 2002Date of Patent: December 27, 2005Assignee: Organogenesis Inc.Inventors: Maury D. Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller
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Patent number: 6855542Abstract: The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates sandwiching a compressible gasket and a substantially incompressible stop can be adjusted using a gasket that forms a fluid-tight seal between the plates at a plurality of levels of compression. The invention enables the culture of cells between substantially parallel and rigid plates in which a relatively large volume can be used to seed the cells and the holdup volume reduced for perfusion without opening or otherwise disassembling the system to compromise its liquidtightness and sterility. The new closed, modular and scalable cell-culturing chamber can be thus perfused and used to culture cells (e.g., hepatocytes) with high levels of cell function in organ (e.g.Type: GrantFiled: December 19, 2002Date of Patent: February 15, 2005Assignee: Organogenesis Inc.Inventors: Paul A. DiMilla, Maury D. Cosman, Rachel Halych, Lisa Romito, Chris Gemmeti, Kevin Odlum
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Patent number: 6759245Abstract: The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver, assist systems, for production of cells, for production of cell-derived products, such as, proteins or viruses, or for systems to treat biological liquids to remove toxins, such as, ammonia, or add cell-synthesized products, or both.Type: GrantFiled: June 21, 2000Date of Patent: July 6, 2004Assignees: The General Hospital Corporation, Organogenesis Inc.Inventors: Mehmet Toner, Arno W. Tilles, Ulysses J. Balis, Martin L. Yarmush, Maury D. Cosman, Paul A. Dimilla
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Publication number: 20030234469Abstract: An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts and spanning between the opposing mounts are a mandrel, a porous rod, and a spring-loaded roller held in parallel arrangement; a guide for aligning and engaging the mandrel on the opposing mounts; and a means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod has a lumen running its length and has pores that communicate between the lumen of the porous rod through to the surface of the rod for water to uniformly pass through. The spring-loaded roller runs along the length of the porous rod creating a line of contact between the roller and the mandrel. The mandrel is contacted with a planar sheet of matrix and is rotated such that successive portions of the matrix contact the porous rod and become lightly moistened by the water passing through the pores of the porous rod and become wrapped around the mandrel to form a tube construct.Type: ApplicationFiled: December 19, 2002Publication date: December 25, 2003Applicant: Organogenesis, Inc.Inventors: Maury D. Cosman, Kristen Billiar, Ryan Mercer, Bruce Miller
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Publication number: 20030157709Abstract: The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates sandwiching a compressible gasket and a substantially incompressible stop can be adjusted using a gasket that forms a fluid-tight seal between the plates at a plurality of levels of compression. The invention enables the culture of cells between substantially parallel and rigid plates in which a relatively large volume can be used to seed the cells and the holdup volume reduced for perfusion without opening or otherwise disassembling the system to compromise its liquidtightness and sterility. The new closed, modular and scalable cell-culturing chamber can be thus perfused and used to culture cells (e.g., hepatocytes) with high levels of cell function in organ (e.g.Type: ApplicationFiled: December 19, 2002Publication date: August 21, 2003Applicant: Organogenesis, Inc.Inventors: Paul A. DiMilla, Maury D. Cosman, Rachel Halych, Lisa Romito, Chris Gemmiti, Kevin Odlum
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Publication number: 20030017142Abstract: The invention features-modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver, assist systems, for production of cells, for production of cell-derived products, such as, proteins or viruses, or for systems to treat biological liquids to remove toxins, such as, ammonia, or add cell-synthesized products, or both.Type: ApplicationFiled: July 15, 2002Publication date: January 23, 2003Applicant: The General Hospital Corporation, a Massachusetts corporationInventors: Mehmet Toner, Arno W. Tilles, Ulysses J. Balis, Martin L. Yarmush, Maury D. Cosman, Paul A. Dimilla
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Patent number: 6465252Abstract: The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver, assist systems, for production of cells, for production of cell-derived products, such as, proteins or viruses, or for systems to treat biological liquids to remove toxins, such as, ammonia, or add cell-synthesized products, or both.Type: GrantFiled: June 21, 2000Date of Patent: October 15, 2002Assignees: The General Hospital Corporation, Organogenesis Inc.Inventors: Mehmet Toner, Arno W. Tilles, Ulysses J. Balis, Martin L. Yarmush, Maury D. Cosman, Paul A. Dimilla