Abstract: A method of detecting an analyte in a body fluid sample using a mobile device having a camera. An image is obtained with the camera of a test field having the body fluid sample applied thereto, causing an optical detection reaction. An algorithm is then performed to determine a potential detection of an optical detection feature and a potential item of intensity information. The potential item of intensity information is weighted with a known item of position probability information. The known item of position probability information is a probability of a potential item of intensity information on the optical detection reaction being a valid item of intensity information. The analyte is detected considering the weighted potential item of intensity information for differentiating a valid from an invalid item of intensity information. A calibration process is then performed in which the known item of position probability information is selected.

Abstract: A method of performing an analytical measurement includes using a camera of a mobile device to capture a time series of images of at least a part of a medical article. From this, image-derived position information on a relative position of the mobile device and the medical article is derived, thereby generating a first time series of position information. A sensor captures measurement information on the relative position of the mobile device and the medical article. Measurement-derived position information is used to generate a second time series of position information, and the first and second time series of position information are combined to generate an augmented time series of position information. From this, guidance is provided to a user to move the mobile device and the medical article into a relative target position. A mobile device, a kit and a computer program are also disclosed.

Abstract: An analytical method for determining a concentration of an analyte is disclosed. In this method, an image of an optical test strip having a body fluid applied thereto is obtained with a camera of a mobile device. Local temperature information is received at a current location of the mobile device from a temperature source such as a remote weather information service or temperature sensor. Additional local temperature information is received by the mobile device from a thermochromic field provided on the test strip and/or on a color reference card. A processor determines a correction temperature and/or a correction temperature function using the local temperature information. The processor also determines the analyte concentration from the image captured and taking into account the correction temperature information.

Abstract: A method of determining a property of a body fluid sample using a database and first and second mobile devices each having a camera and a processor is disclosed. The method uses an optical test element having a reagent test region and a unique identifier associated with the optical test element. In the inventive method, a first image is captured of the test element using the first mobile device before the sample is applied and a second image is captured of the test element after the sample is applied. The first and second images both capture a unique identifier. It is verified whether the unique identifiers in the first and second images are identical and whether a minimum waiting time has elapsed. Depending upon the results of the verification, further evaluation can be aborted or the property of the sample can be determined using the second image.

Abstract: A computer-implemented method of operating a cloud server for providing blacklist information includes a cloud-based blacklist database on the cloud server that has blacklist information on a plurality of mobile devices with cameras. The blacklist information relates to suitability of the mobile devices' hardware and software for performing an analytical measurement. A mobile device may receive upon request blacklist information from the blacklist database concerning the suitability of the requesting mobile device's hardware and software for performing the analytical measurement. The cloud server may receive individual check result information from a sending mobile device concerning the suitability of the sending mobile device's hardware and software for performing the analytical measurement. The individual check result information may be evaluated to determine if the blacklist information on the blacklist database should be updated.

Abstract: A method of determining the concentration of an analyte in a sample of a body fluid with a mobile device having a camera is disclosed. The camera captures an image of a color reference card and of a reagent test field of an optical test strip having a sample applied to it. A predetermined pixel-based mean tone map correction is applied to the image obtained, which results in a first intensity-corrected image. Local brightness information is derived from the first intensity-corrected image. A mobile device-specific tone map correction is applied to the first intensity-corrected image, taking into account the local brightness information. A second intensity-corrected image is thereby obtained. Analyte concentration is determined based on a color formation reaction of the test field by using the second intensity-corrected image. Optionally, a color correction may be derived and applied to the second intensity-corrected image to obtain an intensity-corrected and color-corrected image.

Abstract: A method of performing an analytical measurement includes using a camera of a mobile device to capture a time series of images of at least a part of a medical article. From this, image-derived position information on a relative position of the mobile device and the medical article is derived, thereby generating a first time series of position information. A sensor captures measurement information on the relative position of the mobile device and the medical article. Measurement-derived position information is used to generate a second time series of position information, and the first and second time series of position information are combined to generate an augmented time series of position information. From this, guidance is provided to a user to move the mobile device and the medical article into a relative target position. A mobile device, a kit and a computer program are also disclosed.

Abstract: An optical test strip (118) for measuring an analyte concentration in a sample of bodily fluid is disclosed.

Abstract: Systems and methods for measuring an analyte include devices configured to perform an analyte testing operation. The devices include a wearable electronic device and a remote device operatively connected to each other and each having a processor, the processors cooperating with each other in the execution of program instructions to measure an analyte. The wearable electronic device includes a camera configured to generate a video stream, which is analyzed to identify missing test components, to identify the application of a body fluid on a test strip where the sample undergoes changes in one or more optical properties, the image of which is analyzed to determine a level of the analyte. The wearable electronic device further includes a head-up display (HUD) for providing output messages to the user relating to the performance and status of the analyte testing operation.

Abstract: A computer-implemented method of determining a numerical analyte result value corresponding to a concentration of an analyte in a sample of a bodily fluid of a subject applied to a reagent test region, that includes step (a) determining a numerical analyte result value based on an image of the reagent test region by using an algorithm which takes into account one or more parameters, each parameter being adapted to take more than one value, step (b) displaying the numerical analyte result value and/or a corresponding analyte value range and/or a corresponding message on a display device and step (c) automatically checking for available updated values for one or more of the parameters on a remote server before executing step (a), and, for each available updated value, updating the corresponding parameter value to be taken into account in step (a).

Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.

Abstract: A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source.

Abstract: A glucose test arrangement is provided for use in a handheld meter. The arrangement comprises a disposable test pad responsive to glucose in a body fluid, and a supporting member adapted to support the test pad at an application site for applying body fluid from a user's skin onto a receiving area of the test pad. The receiving area faces away from the supporting member. One or more spacer elements are arranged on the supporting member adjacent to the test pad, wherein the one or more spacer elements have a skin-contacting end section which protrudes above the receiving area.

Abstract: A method of determining concentration of an analyte in a body fluid using a mobile device having a camera is disclosed. In the inventive method, the camera is used to take a series of calibration images of a region of interest of an object. The calibration images differ in their brightness. A key calibration figure is derived from each calibration image, the key calibration images being characteristic for a tone mapping function of the mobile device. A probable tone mapping function of the mobile device is determined by taking into account the key calibration figures. An analysis image is taken of at least part of a test field of an optical test strip, the test field having a body fluid applied thereto. Analyte concentration is determined from the analysis image of the test field by taking into account the probable tone mapping function of the mobile device.

Abstract: A method of evaluating the suitability of a mobile device for performing an analytical measurement based on a color formation reaction. The capability of the mobile device to have relevant settings of the mobile device controlled by software running on the mobile device is evaluated. The relevant settings pertain to image raw data processing steps to be carried out by the mobile device and may include a color space transformation and a tone mapping transformation. When the evaluation indicates that the mobile device is capable of having the relevant settings controlled by the software, control information indicating that the mobile device is suitable for performing the analytical measurement is provided. When the evaluation indicates that the mobile device is not capable of having the relevant settings controlled by the software, control information indicating that the mobile device is unsuitable for performing the analytical measurement is provided.

Abstract: A method is disclosed for determining concentration of an analyte in a body fluid with a mobile device having a camera. The camera captures an image of an optical test strip having a test field. The analyte concentration value is determined from color formation of the test field. Provided in the mobile device is a correlation for transforming color formation of the test field into analyte concentration. Also provided in the mobile device is an item of clearance information indicating a level of confidence for the correlation. When the item of clearance information indicates a sufficient level of confidence for the correlation, the mobile device indicates to a user that the capturing of the image does not require using a color reference card. Further disclosed are a method of controlling analytical measurements, a mobile device, a system for controlling analytical measurements and computer programs for performing and/or controlling analytical measurements.

Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.

Abstract: A method of determining an analyte concentration in a body fluid using a mobile device with a camera is disclosed. A corresponding computer program, a non-transitory computer-readable storage medium, a corresponding mobile device, and a corresponding kit are also disclosed. In step a of the method, a numerical analyte result value from an image of a color formation of a reagent test region is determined. In step b, the numerical analyte result value and/or a corresponding analyte value range and/or a corresponding message is displayed. In step c), after step a) and before step b), an upper bias is added to the numerical analyte result value if it exceeds an upper threshold value, or a lower bias is subtracted if it falls below a lower threshold value, or it is kept unchanged it neither threshold value is passed.

Abstract: A method of determining analyte concentration in a body fluid with a mobile device having a camera. A user is prompted to apply body fluid to an optical test strip and then waits a predetermined minimum waiting time. The camera captures an image of part of the test field having the body fluid applied thereto. Analyte concentration is determined based on the image captured. The determination includes estimating a point in time of sample application to the test field by taking into account time-dependent information derived from the image captured using a first color channel of a color space. The determination also estimates the concentration of the analyte by taking into account concentration-dependent information derived from the image using a second color channel of the color space.