Abstract: A method of determining analyte concentration in a body fluid with a mobile device having a camera. A user is prompted to apply body fluid to an optical test strip and then waits a predetermined minimum waiting time. The camera captures an image of part of the test field having the body fluid applied thereto. Analyte concentration is determined based on the image captured. The determination includes estimating a point in time of sample application to the test field by taking into account time-dependent information derived from the image captured using a first color channel of a color space. The determination also estimates the concentration of the analyte by taking into account concentration-dependent information derived from the image using a second color channel of the color space.

Abstract: A method for generating a module configured to determine concentration of an analyte in a sample of a body fluid is disclosed. The method includes providing a first set of measurement data derived from images of one or more test strips indicating a color transformation in response to a body fluid containing an analyte. The images can be recorded by multiple devices with differing cameras, software and/or hardware device configurations for image recording and image data processing. A neural network model can be generated in a machine learning process applying an artificial neural network and a module configured to determine concentration of an analyte in a second sample of a body fluid can be generated. Further, the present disclosure includes a system for generating the module as well as a method and a system for determining concentration of an analyte in a sample of a bodily fluid.

Abstract: A method of determining analyte concentration in a body fluid with a mobile device having a camera. A user is prompted to apply body fluid to an optical test strip and then waits a predetermined minimum waiting time. The camera captures an image of part of the test field having the body fluid applied thereto. Analyte concentration is determined based on the image captured. The determination includes estimating a point in time of sample application to the test field by taking into account time-dependent information derived from the image captured using a first color channel of a color space. The determination also estimates the concentration of the analyte by taking into account concentration-dependent information derived from the image using a second color channel of the color space.

Abstract: A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source.

Abstract: A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source.

Abstract: A calibration method for calibrating a camera for detecting an analyte in a sample is disclosed. A plurality of different color coordinate systems and a set of test samples are provided. The test samples are applied to test elements that have test fields for producing an optically detectable reaction. Images of the colored test fields are acquired using the camera and color coordinates for the images are generated. The color coordinates that are generated are transformed into a set of measured concentrations by using a set of coding functions. The set of measured concentrations is compared with the known concentrations of the test samples and a best match color coordinate system of the plurality of color coordinate systems is determined. A best match coding function of the plurality of coding functions is also determined.

Abstract: A method is disclosed for controlling auto-exposure settings of a mobile device when capturing an image of a color reference card and of a test field. Provided are a color reference card and an optical test strip having the test field with a sample applied thereto. The color reference card has different color reference fields having known reference color values and one or more gray background fields having defined gray values. An exposure metering area is set and auto-exposure settings are determined based on a scene in the exposure metering area. The scene has at least part of the test field and at least part of the different color reference fields and the one or more gray background fields. The camera captures an image of the scene using the determined auto-exposure settings. A method of determining concentration of analyte in a sample by using a mobile device is also disclosed.

Abstract: A method of determining concentration of an analyte in a body fluid uses a mobile device having a camera and an ambient light detector. The ambient light detector has an ambient light sensor and/or an additional camera. An ambient light check is performed. In the ambient light check, ambient light is used to determine an item of ambient light information. If a validity criterion is determined to be met, the concentration of the analyte is determined by evaluating an image of at least a part of a reagent test region of an optical test strip having a sample of body fluid applied thereto. The image is captured by the camera. A mobile device, a kit, a computer program and a computer-readable storage medium are also disclosed.

Abstract: A test strip fixation device for use in a method of determining analyte concentration in a body fluid using a mobile device with a camera. The device has top and bottom surfaces, has an essentially planar shape, and also has a cut-out portion configured for application of a body fluid sample. The top surface has color reference fields with known reference color values, including grey and non-grey reference fields. The grey reference fields are symmetrically arranged around the cut-out portion and around at least some of the non-grey color reference fields. The top surface also has position detection code elements. The bottom surface has a connector configured for detachable connection of an optical test strip relative to the test strip fixation device, and a reagent test region of the test strip can be aligned with the cut-out portion. A method of using the device is also disclosed.

Abstract: A method of performing an analytical measurement includes using a camera of a mobile device to capture a time series of images of at least a part of a medical article. From this, image-derived position information on a relative position of the mobile device and the medical article is derived, thereby generating a first time series of position information. A sensor captures measurement information on the relative position of the mobile device and the medical article. Measurement-derived position information is used to generate a second time series of position information, and the first and second time series of position information are combined to generate an augmented time series of position information. From this, guidance is provided to a user to move the mobile device and the medical article into a relative target position. A mobile device, a kit and a computer program are also disclosed.

Abstract: A method of determining the concentration of an analyte in a sample of a body fluid with a mobile device having a camera is disclosed. The camera captures an image of a color reference card and of a reagent test field of an optical test strip having a sample applied to it. A predetermined pixel-based mean tone map correction is applied to the image obtained, which results in a first intensity-corrected image. Local brightness information is derived from the first intensity-corrected image. A mobile device-specific tone map correction is applied to the first intensity-corrected image, taking into account the local brightness information. A second intensity-corrected image is thereby obtained. Analyte concentration is determined based on a color formation reaction of the test field by using the second intensity-corrected image. Optionally, a color correction may be derived and applied to the second intensity-corrected image to obtain an intensity-corrected and color-corrected image.

Abstract: A method of evaluating the quality of a color reference card having multiple color reference fields. The quality refers to whether the color reference card is usable for a method for determining concentration of analyte in a body fluid and/or to the degree of suitability or reliability of the color reference card for use with a method for determining analyte concentration in a body fluid. In the inventive method, an image is captured of at least a part of the color reference card using a mobile device camera. Measured color reference values are determined from the image for one or more of the color reference fields and a relationship between one or more of the measured reference color values and corresponding known reference color values is determined. The determined relationship is used to assess the quality of the color reference card. A kit and mobile device are also disclosed.

Abstract: An analytical method for determining a concentration of an analyte is disclosed. In this method, an image of an optical test strip having a body fluid applied thereto is obtained with a camera of a mobile device. Local temperature information is received at a current location of the mobile device from a temperature source such as a remote weather information service or temperature sensor. Additional local temperature information is received by the mobile device from a thermochromic field provided on the test strip and/or on a color reference card. A processor determines a correction temperature and/or a correction temperature function using the local temperature information. The processor also determines the analyte concentration from the image captured and taking into account the correction temperature information.

Abstract: This disclosure refers to an adjustment method for adjusting a setup for an analytical method of determining a concentration of an analyte in a bodily fluid based on a color formation reaction in an optical test strip mobile device for performing analytical measurements. This disclosure further relates to a mobile device configured for performing the adjustment method, a computer program and a computer-readable storage medium for performing the adjustment method and a kit comprising a test strip or a dummy test strip and at least one of the mobile device, the computer program and the computer-readable storage medium. The method, device, computer program, storage media and kit specifically may be used in medical diagnostics, for example, qualitatively or quantitatively detect analytes in body fluids, such as for detecting glucose in blood and/or interstitial fluid. Other fields of application of this disclosure, however, are feasible.

Abstract: A method of performing an analytical measurement based on a color formation reaction in an optical test strip by using a mobile device having a camera. An optical test strip having a test field is provided. The camera captures a first image of at least part of the test field before a sample is applied and a second image after the sample is applied. The mobile device indicates where to take the second image so that the first and second images are taken at similar local positions with respect to at least one environmental feature that has a fixed and/or unchanged position between the capturing of the first and second images. An analytical measurement result value is then determined by using the first and second images. A computer program, a computer-readable storage medium, a mobile device and a kit for performing an analytical measurement are also disclosed.

Abstract: A method is disclosed for determining concentration of an analyte in a body fluid with a mobile device having a camera. The camera captures an image of an optical test strip having a test field. The analyte concentration value is determined from color formation of the test field. Provided in the mobile device is a correlation for transforming color formation of the test field into analyte concentration. Also provided in the mobile device is an item of clearance information indicating a level of confidence for the correlation. When the item of clearance information indicates a sufficient level of confidence for the correlation, the mobile device indicates to a user that the capturing of the image does not require using a color reference card. Further disclosed are a method of controlling analytical measurements, a mobile device, a system for controlling analytical measurements and computer programs for performing and/or controlling analytical measurements.

Abstract: A method of performing an analytical measurement based on a color formation reaction in an optical test strip by using a mobile device having a camera, a display and a position sensor. An optical test strip having a test field is provided. The camera captures a first image of the test field before a sample is applied and a second image after the sample is applied. An item of admissibility information, based on one or both of position sensor data and local position data, is determined. Admissibility is indicated when the position of the mobile device is substantially the same for capturing the first and the second image. When admissibility is indicated, an analytical measurement takes place. Further, a computer program, a computer-readable storage medium, a mobile device and a kit are disclosed.

Abstract: A method for adjusting a measurement setup used in an analytical method. The method includes a plurality of users carrying out analyte measurements that involve capturing images of an optical test strip having a test field and obtaining training data. The training data is then used to identify similarities and to identify a plurality of user profiles according to the similarities. Then, profile-specific measurement setup adjustments for at least one of the user profiles are provided for the individual user profile. An analytical method, an adjustment system and a mobile device are also disclosed.

Abstract: A method of determining concentration of an analyte in a body fluid using a mobile device having a camera is disclosed. In the inventive method, angular orientation of the mobile device relative to the test element is determined by using sensor data of a sensor integrated into the mobile device. The angular orientation of the mobile device relative to the test element is subjected to a validity test. Taking into account the result of the validity test, an image of at least part of a test strip is captured and concentration of analyte in a body fluid sample applied to the test strip can be determined.

Abstract: A method of determining concentration of an analyte in a body fluid using a mobile device having a camera is disclosed. In the inventive method, the camera is used to take a series of calibration images of a region of interest of an object. The calibration images differ in their brightness. A key calibration figure is derived from each calibration image, the key calibration images being characteristic for a tone mapping function of the mobile device. A probable tone mapping function of the mobile device is determined by taking into account the key calibration figures. An analysis image is taken of at least part of a test field of an optical test strip, the test field having a body fluid applied thereto. Analyte concentration is determined from the analysis image of the test field by taking into account the probable tone mapping function of the mobile device.