Patents by Inventor Max Brugger

Max Brugger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4159981
    Abstract: The new hypocalcaemically active peptides of formula I ##STR1## and corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the asparagine radical, their dimers, especially those in which 2 identical peptide sequences (1-32 and 1'-32') are joined in an anti-parallel arrangement via the cysteine radicals 1,7' and 7,1' by means of a disulfide bond, and derivatives are useful as hypocalcaemic agents and are prepared by splitting off groups protecting at least one amino or one carboxyl group or oxidizing the corresponding sulfides to the disulfides or condensing together adequate peptides.
    Type: Grant
    Filed: October 4, 1977
    Date of Patent: July 3, 1979
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Rittel, Max Brugger, Bruno Kamber, Bernhard Riniker, Peter Sieber, Hendrik M. Greven
  • Patent number: 3956260
    Abstract: Synthetic hypocalcaemic dotriacontapeptide of the formulaH-Cys-Ser-Asn-Leu-Ser--Thr-Cys-Val-Leu-Ser-Ala-Tyr-Try-Arg-Asn-Leu-Asn-Asn- Phe-His-Arg-Phe-Ser-Gly-Met-Gly-Phe-Gly-Pro-Glu-Thr-Pro-OH Iand analogues and derivatives, salts and complexes thereof and process for their manufacture.
    Type: Grant
    Filed: December 10, 1971
    Date of Patent: May 11, 1976
    Assignee: Ciba-Geigy Corporation
    Inventors: Max Brugger, Friedrich Werner Kahnt, Bruno Kamber, Robert Neher, Bernhard Riniker, Werner Rittel, Peter Sieber, Herbert Zuber, Hendrik Marie Greven
  • Patent number: 3948876
    Abstract: Peptides of the calcitonin type when obtained by synthesis can be purified in a simple manner by forming inner salts, which precipitate from aqueous solutions of salts of the peptides with acids or bases when these solutions are adjusted to the isoelectric range. Impurities remain in solution, while the inner salts separate practically quantitatively. The precipitation is completed after several hours. The peptides can then be recuperated by treatment with an acid, especially a therapeutically suitable acid. The process affords products which are superior to those obtained by purification methods hitherto known and gives higher yields. Other long-chain peptides such as ACTH, insulin or glucagon cannot be purified in this manner.
    Type: Grant
    Filed: December 3, 1974
    Date of Patent: April 6, 1976
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Rittel, Max Brugger, Bernhard Riniker
  • Patent number: 3934008
    Abstract: The new hypocalcaemically active peptides of formula Ih-cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-P he-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-val-Gly-Ala-Pro-OHand corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the asparagine radical, their dimers, especially those in which 2 identical peptide sequences (1-32 and 1'-32') are joined in an anti-parallel arrangement via the cysteine radicals 1,7' and 7,1' by means of a disulfide bond, and derivatives are useful as hypocalcaemic agents and are prepared by splitting off groups protecting at least one amino or one carboxyl group or oxidizing the corresponding sulfides to the disulfides or condensing together adequate peptides.
    Type: Grant
    Filed: July 14, 1972
    Date of Patent: January 20, 1976
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Rittel, Max Brugger, Bruno Kamber, Bernhard Riniker, Peter Sieber, Hendrik Marie Greven