Abstract: The present invention is situated in the field of multimers used for targeted therapies. More particularly, the present invention provides a dimeric protein complex comprising a first polypeptide comprising a first functional component and the C-terminal fragment of the C4bp beta-chain, wherein said first functional component is coupled to the C-terminus of the C-terminal fragment of the C4bp beta-chain; and a second polypeptide comprising a second functional component and the C-terminal C4bp beta-chain, wherein said second functional component is coupled to the C-terminus of the C-terminal fragment of the C4bp beta-chain; wherein said first and second polypeptides are identical or different and wherein said first and second functional components are proteins or polypeptides. Further provided are nucleic acids encoding said first or second polypeptide of the dimeric protein complex and pharmaceutical compositions comprising the dimeric protein complex.

Abstract: A penetration fitting assembly includes a base assembly including first and second gasket halves and first and second base halves, a pipe gasket, and a cap assembly including first and second cap halves. The gasket halves each include first and second semi-annular portions, and the base halves each include a semi-annular face plate defining openings, a semi-annular groove in a front surface of the face plate, a reinforcement flange extending along an outer peripheral edge of the face plate, and a second semi-annular groove in an outer surface of the reinforcement flange. The pipe gasket includes an annular portion defining a central opening, and stem portions extending in opposite directions from the annular portion. The cap halves each include a semi-cylindrical sidewall defining a semi-annular groove, a semi-circular cap plate connected to the semi-cylindrical sidewall, and a channel defined by the semi-circular cap plate.

Abstract: An immunogenic composition containing at least one antigen and at least one adjuvant including at least one Metal-Organic Framework including an inorganic part based on aluminum and an organic part based on polydentate ligand chosen from fumarate, muconate, mesaconate, oxalate, oxaloacetate, succinate, malate, citrate, aconitate, isophthalate, substituted isophthalate, 2,5-thiophenedicarboxylate, 2,5-furandicarboxylate, trimesate, trimellitate and pyromellitate, the antigen being immobilized at least within the Metal-Organic Framework.

Abstract: A penetration fitting assembly includes a base assembly including first and second gasket halves and first and second base halves, a pipe gasket, and a cap assembly including first and second cap halves. The gasket halves each include first and second semi-annular portions, and the base halves each include a semi-annular face plate defining openings, a semi-annular groove in a front surface of the face plate, a reinforcement flange extending along an outer peripheral edge of the face plate, and a second semi-annular groove in an outer surface of the reinforcement flange. The pipe gasket includes an annular portion defining a central opening, and stem portions extending in opposite directions from the annular portion. The cap halves each include a semi-cylindrical sidewall defining a semi-annular groove, a semi-circular cap plate connected to the semi-cylindrical sidewall, and a channel defined by the semi-circular cap plate.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A portable pump and fuel containment system includes a portable base assembly including a lower support and wheels, a container on the lower support including an interior volume and inlet and outlet ports in fluid communication with the interior volume, and a liquid transfer assembly coupled to the portable base assembly. The liquid transfer assembly includes a pump, a three-way control valve, a flexible transfer line having a first transfer line segment coupled to a first inlet of the three-way control valve and a second transfer line segment extending from the outlet port to a second inlet of the three-way control valve, and a flexible return line having a first end coupled to the outlet of the pump and a second end detachably coupled to the inlet port of the container. An outlet of the three-way control valve is connected to an inlet of the pump.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A portable pump and fuel containment system includes a portable base assembly including a lower support and wheels, a container on the lower support including an interior volume and inlet and outlet ports in fluid communication with the interior volume, and a liquid transfer assembly coupled to the portable base assembly. The liquid transfer assembly includes a pump, a three-way control valve, a flexible transfer line having a first transfer line segment coupled to a first inlet of the three-way control valve and a second transfer line segment extending from the outlet port to a second inlet of the three-way control valve, and a flexible return line having a first end coupled to the outlet of the pump and a second end detachably coupled to the inlet port of the container. An outlet of the three-way control valve is connected to an inlet of the pump.

Abstract: A penetration fitting assembly includes a pipe gasket having an annular portion defining a central opening and first and second stem portions extending in opposite directions from the annular portion, an inner ring assembly configured to surround the pipe gasket and including first and second inner ring halves, a ring gasket assembly configured to surround the inner ring assembly and including first and second ring gasket halves, a wall gasket, an outer ring assembly configured to surround the ring gasket assembly and including first and second outer ring halves, and a clamp configured to surround the outer ring assembly. When the penetration fitting assembly is installed, the outer ring assembly compresses the wall gasket against the wall of the sump, the clamp compresses the ring gasket assembly between the inner ring assembly and the outer ring assembly, and the clamp compresses the pipe gasket against the pipe or conduit.

Abstract: A penetration fitting assembly includes a base assembly including first and second gasket halves and first and second base halves, a pipe gasket, and a cap assembly including first and second cap halves. The gasket halves each include first and second semi-annular portions, and the base halves each include a semi-annular face plate defining openings, a semi-annular groove in a front surface of the face plate, a reinforcement flange extending along an outer peripheral edge of the face plate, and a second semi-annular groove in an outer surface of the reinforcement flange. The pipe gasket includes an annular portion defining a central opening, and stem portions extending in opposite directions from the annular portion. The cap halves each include a semi-cylindrical sidewall defining a semi-annular groove, a semi-circular cap plate connected to the semi-cylindrical sidewall, and a channel defined by the semi-circular cap plate.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: The invention relates to a protein construct, comprising (i) a targeting moiety that is capable of binding to a target cell, and (ii) an effector immunogenic moiety that is capable of triggering an existing, vaccine-induced or natural, immune response. The protein construct, that is preferably in the form of a heteromultimeric protein, is useful for redirecting an immune response that was pre-existing in a patient, toward an undesired target cell.

Abstract: The present invention provides a pharmaceutical composition or crystalline composition with a specific dissolution profile, which comprises suberoylanilide hydroxamic acid or a pharmaceutically acceptable salt or hydrate thereof as an active ingredient. The present invention provides a process of producing said crystalline composition or pharmaceutical composition. The present invention also provides compositions with a specific particle size distribution.

Abstract: The invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d complement bound to a carrier consisting of erythrocytes or microparticles. The invention also concerns a method for analyzing in vitro the risk of humoral organ transplant rejection, which consists in determining the amount of component of C4d component fixed on the erythrocytes contained in a blood sample from a patient.