Abstract: Disclosed is a peptide including (a) a cell membrane penetration (CMP) sequence; and (b) one or more TDP-43 phosphorylation-blocking (PB) sequences. Also disclosed is a method of reducing the phosphorylation of TDP-43 in a cell, the method including: delivering an effective amount of a peptide to the cell, wherein the peptide comprises: (a) a cell membrane penetration (CMP) sequence; and (b) a TDP-43 phosphorylation-blocking (PB) sequence. Also disclosed is a method of treating a disease or pathological condition, the method comprising administering an effective amount of a peptide to a subject in need thereof; wherein the peptide comprises: (a) a cell membrane penetration (CMP) sequence; and (b) one or more TDP-43 phosphorylation-blocking (PB) sequences. Related uses, peptides for use, vectors, polynucleotide, and pharmaceutical compositions are disclosed.

Abstract: The disclosed invention generally relates to newly identified polynucleotide sequences capable of conferring neural plasticity to neurons. Additionally, this application encompasses the complete gene sequences, the polypeptides associated therewith, and methods of using. These methods include the use of the sequences for gene therapy, including the treatment or cure of genetic diseases, for the treatment of degenerative disorders, for the treatment of neuron damage, and for the treatment of learning disorders. Additionally, these sequences are useful to enhance memory and learning capacity.

Abstract: Methods for treatment, processes for preparing, and compositions for delivering selected nucleic acid sequences to cells, primarily of the treatment of neurological disorders and exploring neurological functions, are disclosed. In particular, the invention provides recombinant Herpesvirus vectors with a high rate of expression of selected nucleic acid sequences and/or a low cytopathicity and its associated methods and processes.