Abstract: Provided herein are bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, such as the antibodies and fragments that specifically bind human FLT3 and human CD3. In some aspects, provided herein are optimized humanized, bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, optionally, having certain amino acid substitutions that confer advantageous properties (e.g., optimal antigen binding, manufacturability and/or half-life properties). Also provided herein are pharmaceutical compositions comprising such antibodies or fragments. Also provided herein are methods of use of such antibodies and fragments.

Abstract: A coffee grinder-mixer assembly and method for alternatively producing high yield coffee and regular yield coffee comprising a grinding head, an elongated mixer box, a first elongated shaft mounting auger means and supported for rotation in the mixer box, second elongated shaft concentric with the first shaft for rotation relative to the first shaft, a plurality of paddles mounted on the second shaft, and means for alternatively co-rotating and counter-rotating the first shaft and the second shaft, relative to the other, thereby alternatively to produce high yield and regular yield coffees.