Patents by Inventor Max Fernand Robba

Max Fernand Robba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5290790
    Abstract: The compounds correspond to the general formula ##STR1## in which R.sub.1 represents a hydrogen atom or a group --COR.sub.2, in which R.sub.2 represents a benzene ring, cyclopentylmethyl, cyclohexylmethyl, cyclopentylethyl or cyclohexylethyl groups or cyclopentylamine, cyclohexylamine or phenylamine, chlorophenylamine or dichlorophenylamine groups; R represents a hydrogen atom or a group COR.sub.3, in which R.sub.3 represents an aliphatic group, a cyclane or benzene ring-system, a group a group (CH.sub.2).sup.m R.sub.4, a group --CH.dbd.CHR.sub.8 or a secondary amine group --NH(CH.sub.2).sub.n R.sub.
    Type: Grant
    Filed: December 30, 1991
    Date of Patent: March 1, 1994
    Assignees: National De La Sante et De La Recherche Medicale, Societe Civile Bioprojet, Universite De Caen - Esplanade De La Faix
    Inventors: Jean-Michel Arrang, Monigue Garborg, Jean-Charles M. Lancelot, Jeanne-Marie Lecomte, Max-Fernand Robba, Jean-Charles Schwartz
  • Patent number: 4707487
    Abstract: Compounds of general formula ##STR1## in which R.sub.1 denotes H, CH.sub.3 or C.sub.2 H.sub.5, R denotes H or R.sub.2 and R.sub.2 denotes an alkyl, piperonyl, 3-(1-benzimidazolonyl)-propyl group; a group of formula ##STR2## in which n is 0, 1, 2, or 3, X is a single bond or alternatively --O--, --S--, --NH--, --CO--, --CH.dbd.CH-- or ##STR3## and R.sub.3 is H, CH.sub.3, F, CN or an acyl group; or alternatively a group of formula ##STR4## in which Z denotes an O or S atom or a divalent group NH, N --CH.sub.3 or N --CN, and R.sub.5 denotes an alkyl group, a cycloalkyl group which can bear a phenyl substituent, a phenyl group which can bear a CH.sub.3 or F substituent, a phenylalkyl(1-3 C) group or a naphthyl, adamantyl or p-toluenesulphonyl group. These compounds are useful to control the release of cerebral histamine and to increase the rate of renewal of cerebral histamine.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: November 17, 1987
    Assignees: Institut National de la Sante et de la Recherche Medicale (Inserm), Universite de Caen, Societe Civile Bioprojet
    Inventors: Jean-Michel Arrang, Monique Garbarg, Jean-Charles Lancelot, Jeanne-Marie Lecomte, Max-Fernand Robba, Jean-Charles Schwartz
  • Patent number: 4079140
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are alkyls or alkenyls having 1 to 4 atoms or ##STR2## is pyrrolidino, piperidino, perhydroazepino or morpholino, and RX is a salt-forming moiety. The compounds are prepared by reacting 2-acetyl benzothiophene with ##STR3## The compounds possess a blood plaque aggregation inhibiting property and also possess spasmolytic, analgesic, anti-inflammatory and coronary, cerebral and peripheral vasodilatatory properties.
    Type: Grant
    Filed: March 31, 1976
    Date of Patent: March 14, 1978
    Assignee: Innothera
    Inventors: Max Fernand Robba, Michel Aurousseau
  • Patent number: 4035371
    Abstract: .beta.-[Benzo(b)thienyl-3] propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotanic and local anaesthetic activity.
    Type: Grant
    Filed: January 22, 1976
    Date of Patent: July 12, 1977
    Assignee: Innothera
    Inventors: Max Fernand Robba, Denise Jeanne Claude Duval
  • Patent number: 4005095
    Abstract: Substituted thienyl-acetic acid esters of the formula: ##STR1## in which R.sub.1 and R.sub.2 each, independently is H, CH.sub.3, C.sub.2 H.sub.5, C.sub.3 H.sub.7, OCH.sub.3, SCH.sub.3, Cl Br or NO.sub.2, R.sub.3 is phenyl or cyclohexyl and R.sub.4 is H, or R.sub.3 and R.sub.4 together are cyclohexylidene, n is 2 or 3, and A is monoalkylamino or dialkylamino, each alkyl radical having 1 to 4 carbon atoms, or amino derived from a cycloalkylamine of 5 to 7 chain members which may contain an additional hetero-atom, provided that each of R.sub.1 and R.sub.2 is not H if R.sub.3 is phenyl or cyclohexyl and R.sub.4 is H, racemates, optical isomers, and their pharmaceutically acceptable acid addition salts and quaternary ammonium salts obtained with alkyl halides, have marked activity as peripheral vasodilators, platelet aggregation inhibitors, spasmolytic agents, coronary and cerebral vasodilators, and papaverine-like activity.
    Type: Grant
    Filed: May 20, 1975
    Date of Patent: January 25, 1977
    Assignee: Innothera
    Inventors: Max Fernand Robba, Michel Emile Marie Aurousseau
  • Patent number: 3954780
    Abstract: .beta.-[Benzo(b)thienyl-3]propionic acid derivatives in the form of their amino esters (and salts thereof) are prepared. These compounds have spasmolytic, vasodilatatric, antiserotanic and local anaesthetic activity.
    Type: Grant
    Filed: July 18, 1974
    Date of Patent: May 4, 1976
    Assignee: Innothera
    Inventors: Max Fernand Robba, Denise Jeanne Claude Duval