Patents by Inventor Max Gerecke
Max Gerecke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6174881Abstract: The invention is concerned with hydroxymethyl-imidazodiazepines and their esters of general formula I. These compounds can be used as anxiolytic and/or anticonvulsant and/or muscle relaxant and/or sedative-hypnotic active substances.Type: GrantFiled: September 4, 1997Date of Patent: January 16, 2001Assignee: Hoffman-La Roche Inc.Inventors: Ren{acute over (e)} Borer, Bernd B{umlaut over (u)}ttelmann, Andr{acute over (e)} Szente, Max Gerecke-Jecklin
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Patent number: 5387585Abstract: The novel imidazodiazepine derivatives of the formula: ##STR1## wherein the substituents are as described in the specification, can be used for the control or prevention of epileptic seizures, anxiety, tension and excitation states, sleep disorders, schizophrenic symptoms, hepatic encephalopathy and senile dementia, as well as, in the partial or complete antagonization of undesired side-effects of substances acting on benzodiazepine receptors after over-dosage or after their use in intensive medicine and in anesthesia.Type: GrantFiled: November 15, 1993Date of Patent: February 7, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Rene Borer, Walter Gassner, Max Gerecke, Emilio Kyburz
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Patent number: 4464300Abstract: There are presented benzazepines of the formula ##STR1## wherein either R.sup.1 is hydrogen, lower alkyl, 4-pyridyl or the group --(CH.sub.2).sub.n --NR.sup.6 R.sup.7 and R.sup.2 and R.sup.3 together are an additional bond or R.sup.1 and R.sup.2 together are the oxo group and R.sup.3 is hydrogen or lower alkyl, R.sup.4 is phenyl, o-halophenyl or 2-pyridyl, R.sup.5 is halogen or nitro and either R.sup.6 is hydrogen or lower alkyl and R.sup.7 is hydrogen, lower alkyl, lower alkenyl or lower alkynyl or R.sup.6 and R.sup.7 together with the nitrogen atom are 4-(lower alkyl)-1-piperazinyl or 4-morpholinyl and n is the number 0 or 1, and their pharmaceutically acceptable acid additions salts.The compounds possess interesting psychotropic properties, i.e., pronounced anxiolytic properties have been established in the case of certain representative members of this class of substance.Type: GrantFiled: July 15, 1982Date of Patent: August 7, 1984Assignee: Hoffmann-La Roche Inc.Inventors: Rene Borer, Max Gerecke, Emilio Kyburz
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Patent number: 4363762Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of: ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: December 14, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4359420Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: November 16, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346032Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346031Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346033Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346034Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is <C.dbd.O or <C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346036Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346035Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4346030Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: November 16, 1981Date of Patent: August 24, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4316839Abstract: Imidazodiazepine derivatives of the formula ##STR1## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR2## the dotted line represents the double bond present in groups (a) and (b), D is >C.dbd.O or >C.dbd.S, R.sup.1 is selected from the group consisting of cyano, lower alkanoyl and a group of the formula --COOR.sup.4, R.sup.4 is selected from the group consisting of methyl, ethyl, isopropyl and 2-hydroxyethyl, R.sup.5 is selected from the group consisting of hydrogen, trifluoromethyl and halogen and R.sup.6 is selected from the group consisting of hydrogen, trifluoromethyl, halogen and lower alkyl and either R.sup.2 is hydrogen and R.sup.3 is hydrogen or lower alkyl or R.sup.2 and R.sup.3 together are trimethylene or propenylene and the carbon atom denoted as .gamma.Type: GrantFiled: October 3, 1980Date of Patent: February 23, 1982Assignee: Hoffman-La Roche Inc.Inventors: Max Gerecke, Willy Haefely, Walter Hunkeler, Emilio Kyburz, Hanns Mohler, Lorenzo Pieri, Petar Polc
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Patent number: 4118572Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described, are described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.Type: GrantFiled: March 18, 1977Date of Patent: October 3, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
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Patent number: 4105664Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.Type: GrantFiled: March 18, 1977Date of Patent: August 8, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
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Patent number: 4100173Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described,Are described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.Type: GrantFiled: March 18, 1977Date of Patent: July 11, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
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Patent number: 4091023Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described, are described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.Type: GrantFiled: March 18, 1977Date of Patent: May 23, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
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Patent number: 4044010Abstract: Compounds of the formfulas ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, m and n and X are as hereinafter set forth,Are described. The compounds of formulas I and Ia are useful as neuroleptic agents.Type: GrantFiled: February 4, 1976Date of Patent: August 23, 1977Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
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Patent number: 4032525Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.Type: GrantFiled: December 18, 1974Date of Patent: June 28, 1977Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
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Patent number: 4011222Abstract: Compounds of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as hereinafter set forth, are described. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.Type: GrantFiled: January 12, 1976Date of Patent: March 8, 1977Assignee: Hoffmann-La Roche Inc.Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz