Abstract: Dinitrohalogenated compounds may be utilized by injection in certain clinical situations to provide a possibility of long term control of human malignancy. In some of those settings no other treatment offers such potential. Preparation methods may include acetone, olive oil, microsomes, liposomes, or combinations thereof. Optimum pretreatment management, dosing and injection techniques are described. The unique aspects of the claims included herein include the methods of preparation of the chemical, the technique of injection, the dosage of each injection, and the range of potential tumor histologies. These techniques have resulted for example in successful treatment of locally metastatic scalp melanoma, the treatment for which had previously been uniformly unsuccessful. This example is particularly significant since this is one example of a site that is not otherwise amenable to successful treatment when affected by multiple progressive metastatic nodules.

Abstract: Dinitrohalogenated compounds may be utilized by injection in certain clinical situations to provide a possibility of long term control of human malignancy. In some of those settings no other treatment offers such potential. Preparation methods may include acetone, olive oil, microsomes, liposomes, or combinations thereof. Optimum pretreatment management, dosing and injection techniques are described.