Patents by Inventor Max Moore

Max Moore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide synthesis with alternative solvents
    Publication number: 20050026192
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 3, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Max Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
  • Synthesis of oligonucleotides on solid support
    Patent number: 6822088
    Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: November 23, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Max Moore, Achim H. Krotz, Mark Andrade, Anthony N. Scozzari
  • Synthesis of oligonucleotides on solid support
    Publication number: 20030032795
    Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
    Type: Application
    Filed: July 16, 2002
    Publication date: February 13, 2003
    Inventors: Max Moore, Achim H. Krotz, Mark Andrade, Anthony N. Scozzari