Abstract: A ratchet hinge for a knee or elbow orthosis having a pair of struts, connected to one strut is a pair of plates in spaced relation to one another. The other strut is pivotably connected between the plates and has a slot formed therein for receiving a locking assembly. The plates have a plurality of ratchets on their outer periphery and a locking slot formed in the edge of the plates. The locking assembly has a spring biased locking pin disposed between two plates such that the pin engages the plates to lock the hinge or allow limited movement.

Abstract: An abductor hinge having a first and a second connector. The first connector having a hub with a projection that extends outwardly from the hub and a central bore that extends through the hub and the projection. The second connector has a hub juxtapositioned to the hub of the first connector, and having a recess that frictionally receives the projection. A central bore extends through the hub of the second connector to the recess and is in alignment with the bore of the first connector. A screw extends through the bores of the first and second connectors to secure the connectors together.

Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.

Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.

Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.