Abstract: The invention relates to a pharmaceutical cream preparation for topical application in the form of an oil-in-water (o/w) emulsion, containing the following constituents in the lipophilic phase: (i) an optionally substituted 1-phenyl-2-(1H)-pyridone compound or a pharmaceutically acceptable salt thereof, as an active ingredient, (ii) at least one surface-active solubilising agent having an HLB value between 15 and 20, (iii) at least one emulsifier having an HLB value between 8 and 15, and (iv) optionally other carrier materials and additives known per se selected from the group containing triglycerides, penetration amplifiers, preserving agents and anti-oxidants. The invention also relates to the use of the preparation as a topical cream preparation for the treatment or prophylaxis of skin diseases.

Abstract: A pharmaceutical combination consisting of an effective amount of artesunate and mefloquine and a method of treating malaria is described. The combination of artesunate and mefloquine is very well tolerated if used in a 3-day course of malaria treatment, wherein the dosage of artesunate and mefloquine is each day the same, and it is preferably administered once a day simultaneously. The combination can conveniently be pre-packed in a single blister pack divided into 3 daily units, and the daily units preferably distinguished by different colours. The combination is effectively used especially in the treatment of Plasmodium falciparum malaria, even if resistant to other antimalarial drugs, or malaria caused by mixed malaria parasites.