Abstract: An examples of a system for delivering neurostimulation to a patient may include a stimulation output circuit configured to deliver the neurostimulation, a sensing circuit configured to sense a neural signal indicative of neural responses to the neurostimulation, and stimulation control circuit. The stimulation control circuit may be configured to control the delivery of the neurostimulation using a plurality of stimulation parameters and may be configured to detect morphological features of the neural responses, to produce a neural response parameter using the detected morphological features, to detect a change in the sensed neural signal, to analyze the produced neural response parameter for attributing the detected change to one of a neural activation change in the patient or a body movement of the patient, and to control a dynamically controlled stimulation parameter of the plurality of stimulation parameters using the sensed neural signal and an outcome of the analysis.

Abstract: A system may include an electrode arrangement and a neurostimulator. The electrode arrangement may have a length generally in a rostral-caudal direction and a width generally in a mediolateral direction. The electrode arrangement may include a first set and a second set of electrodes spaced across the width. The neurostimulator may be configured to stimulate a sequence of locations of the patient using subsets of the first set of electrodes, and for each stimulated location in the stimulated sequence of locations identify corresponding response measures for each one of the second set of electrodes. The physiological midline may be inferred or identified from these measurements, which may be used to guide lead placement and/or programming.

Abstract: Methods and systems for closed loop feedback control of electrical neuromodulation are described. Closed loop feedback control is based on sensed electrical potentials, which are used as reference control variables in a feedback control algorithm to adjust the electrical stimulation based on one or more control algorithm parameters. The performance of the closed loop feedback control algorithm may be evaluated, and the feedback algorithm may be adjusted based on its performance. In some instances, the feedback algorithm may be adjusted based on an indication state of the patient.

Abstract: An examples of a system for delivering neurostimulation to a patient may include a stimulation output circuit configured to deliver the neurostimulation, a sensing circuit configured to sense a neural signal indicative of neural responses to the neurostimulation, and stimulation control circuit. The stimulation control circuit may be configured to control the delivery of the neurostimulation using a plurality of stimulation parameters and may be configured to detect morphological features of the neural responses, to produce a neural response parameter using the detected morphological features, to detect a change in the sensed neural signal, to analyze the produced neural response parameter for attributing the detected change to one of a neural activation change in the patient or a body movement of the patient, and to control a dynamically controlled stimulation parameter of the plurality of stimulation parameters using the sensed neural signal and an outcome of the analysis.