Patents by Inventor Maxim Itkin
Maxim Itkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11957102Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: GrantFiled: July 7, 2022Date of Patent: April 16, 2024Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Prashant Sonawane, Maxim Itkin
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Publication number: 20220408679Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: ApplicationFiled: July 7, 2022Publication date: December 29, 2022Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph AHARONI, Prashant SONAWANE, Maxim ITKIN
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Publication number: 20220256794Abstract: A plant comprising a genome having an introgression which comprises a polynucleotide sequence encoding a polypeptide having a terpene synthase activity or a transporter activity, the introgression comprising allelic variation(s) as compared to a genome of a recurrent parent of the plant, is disclosed. Organisms comprising a genome having been genetically modified to express a polypeptide having a terpene synthase activity or a transporter activity are also disclosed. Methods of modulating terpene synthesis or transport of metabolites in organisms, methods of producing plants having a terpene synthase activity of interest, having a terpene profile of interest or having a transporter activity of interest are disclosed. Methods of producing a terpene of interest are also disclosed.Type: ApplicationFiled: May 8, 2020Publication date: August 18, 2022Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Shahar COHEN, Rachel DAVIDOVICH-RIKANATI, Einat BAR, Efraim LEWINSOHN, Adi DORON-FAIGENBOIM, Faris SALAMA, Daniel HASSON, Shahar SARUBERG, Yelena YESELSON, Dalia WOLF, Guy POLTURAK, Maxim ITKIN, Arthur A. SCHAFFER
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Patent number: 11412700Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: GrantFiled: September 1, 2020Date of Patent: August 16, 2022Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Prashant Sonawane, Maxim Itkin
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Publication number: 20220217934Abstract: Provided herein are genetically modified cells and genetically modified plants having increased or decreased expression of a cellulose synthase like G (CSLG) enzyme. These cells and plants may have an increased or decreased content a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin, compared to a corresponding unmodified cell or plant. Also provided herein are methods of producing a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a genetically modified cell, as well as methods of reducing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part, and methods of increasing the content of a steroidal alkaloid, a steroidal saponin, or a triterpenoid saponin in a cell of a plant or a plant part.Type: ApplicationFiled: September 5, 2019Publication date: July 14, 2022Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph AHARONI, Prashant SONAWANE, Maxim ITKIN, Adam JOZWlAK
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Publication number: 20220170063Abstract: Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), epoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT), Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside.Type: ApplicationFiled: December 28, 2021Publication date: June 2, 2022Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Maxim ITKIN, Rachel DAVIDOVICH-RIKANATI, Shahar COHEN, Vitaly PORTNOY, Adi DORON-FAIGENBOIM, Marina PETREIKOV, Shmuel SHEN, Yaakov TADMOR, Yosef BURGER, Efraim LEWINSOHN, Nurit KATZIR, Arthur A. SCHAFFER, Elad OREN
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Publication number: 20200390053Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: ApplicationFiled: September 1, 2020Publication date: December 17, 2020Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph AHARONI, Prashant SONAWANE, Maxim ITKIN
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Patent number: 10806119Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: GrantFiled: September 6, 2018Date of Patent: October 20, 2020Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Prashant Sonawane, Maxim Itkin
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Publication number: 20200215313Abstract: The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.Type: ApplicationFiled: March 20, 2020Publication date: July 9, 2020Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE CHILDREN'S HOSPITAL OF PHILADELPHIAInventors: Maxim Itkin, Yoav Dori
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Patent number: 10639458Abstract: The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.Type: GrantFiled: June 26, 2015Date of Patent: May 5, 2020Assignees: The Trustees of the University of Pennsylvania, The Children's Hospital of PhiladelphiaInventors: Maxim Itkin, Yoav Dori
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Patent number: 10314648Abstract: The subject matter described relates to a coaxial ablation probe and method and system for real time monitoring of ablation progress for percutaneous ablation. The probe includes an anode. The probe further includes a size and shape adjustable cathode cage surrounding the anode, the cathode cage includes a plurality of struts. The anode extends coaxially with respect to the struts that form the cathode cage. The cathode cage defines the treatment volume. Probe insertion and ablation progress will be monitored by a magnetic resonance imaging system.Type: GrantFiled: December 15, 2014Date of Patent: June 11, 2019Assignee: The Trustees of the Universoty of PennsylvaniaInventors: Benjamin Hairan Ge, Maxim Itkin, Charles Nicholas Weber
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Publication number: 20190059314Abstract: The present invention relates to key genes in the biosynthesis of steroidal alkaloids and saponins, including regulatory genes and enzyme-encoding genes, and to use thereof for altering the content of steroidal (glyco)alkaloids or phytosterols in plants. The present invention provides genetically modified plants or gene edited plants with altered content of steroidal (glyco)alkaloids, particularly to Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids and to the increase in phytosterols, including cholesterol or cholestanol in these plants. The present invention also provides methods of altering gene expression.Type: ApplicationFiled: September 6, 2018Publication date: February 28, 2019Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph AHARONI, Prashant Sonawane, Maxim Itkin
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Patent number: 10100322Abstract: The present invention relates to genetically modified plants by key genes involved in the biosynthesis of steroidal alkaloids. These plants have altered content of steroidal (glyco)alkaloids. Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids are provided.Type: GrantFiled: June 2, 2014Date of Patent: October 16, 2018Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph Aharoni, Maxim Itkin
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Publication number: 20170283844Abstract: Isolated mogroside and mogrol biosynthetic pathway enzyme polypeptides useful in mogroside biosynthesis are provided. Mogroside biosynthetic pathway enzymes of the invention include squalene epoxidase (SE), expoxy hydratase (EH), cytochrome p450 (Cyp), cucurbitadienol synthase (CDS) and udp-glucosyl-transferase (UGT). Also provided are methods of producing a mogroside using the isolated mogroside and mogrol biosynthetic enzyme polypeptides, the methods comprising contacting a mogrol and/or a glycosylated mogrol (mogroside) with at least one UDP glucose glucosyl transferase (UGT) enzyme polypeptide of the invention catalyzing glucosylation of the mogrol and/or the glucosylated mogrol to produce a mogroside with an additional glucosyl moietie(s), thereby producing the mogroside.Type: ApplicationFiled: September 10, 2015Publication date: October 5, 2017Inventors: Maxim ITKIN, Rachel DAVIDOVICH-RIKANATI, Shahar COHEN, Vitaly PORTNOY, Adi DORON-FAIGENBOIM, Marina PETREIKOV, Shmuel SHEN, Yaakov TADMOR, Yosef BURGER, Efraim LEWINSOHN, Nurit KATZIR, Arthur A. SCHAFFER, Elad OREN
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Publication number: 20170197066Abstract: The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.Type: ApplicationFiled: June 26, 2015Publication date: July 13, 2017Inventors: Maxim Itkin, Yoav Dori
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Publication number: 20160317212Abstract: The subject matter described relates to a coaxial ablation probe and method and system for real time monitoring of ablation progress for percutaneous ablation. The probe includes an anode. The probe further includes a size and shape adjustable cathode cage surrounding the anode, the cathode cage includes a plurality of struts. The anode extends coaxially with respect to the struts that form the cathode cage. The cathode cage defines the treatment volume. Probe insertion and ablation progress will be monitored by a magnetic resonance imaging system.Type: ApplicationFiled: December 15, 2014Publication date: November 3, 2016Inventors: Benjamin Hairan Ge, Maxim Itkin, Charles Nicholas Weber
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Publication number: 20160122775Abstract: The present invention relates to genetically modified plants by key genes involved in the biosynthesis of steroidal alkaloids. These plants have altered content of steroidal (glyco)alkaloids. Solanaceous crop plants with reduced content of antinutritional steroidal glycoalkaloids are provided.Type: ApplicationFiled: June 2, 2014Publication date: May 5, 2016Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.Inventors: Asaph AHARONI, Maxim ITKIN
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Publication number: 20120236996Abstract: A radiation control system and method are provided in which radiation delivered to a patient and/or the operator of the equipment is minimized. The radiation control system may be used in a large variety of applications including applications in which radiation source is used to inspect an object, such as, for example, medical imaging, diagnosis and therapy, in manufacturing operation using radiation, in airports scanning systems, in different security setups, and in nuclear reactors automation and process control. The radiation control system and method may also be used with 3D imaging.Type: ApplicationFiled: December 5, 2011Publication date: September 20, 2012Applicant: Intellirad Control, Inc.Inventors: Allon Guez, Maxim Itkin