Patents by Inventor Maxim Sergeev

Maxim Sergeev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal oxide catalyzed radiofluorination
    Patent number: 9895454
    Abstract: Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: February 20, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Maxim Sergeev, Federica Morgia, Robert Michael Van Dam, Mark Lazari
  • METAL OXIDE CATALYZED RADIOFLUORINATION
    Publication number: 20170224851
    Abstract: Inter alia, the first titania-catalyzed [18F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [18F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.
    Type: Application
    Filed: July 2, 2015
    Publication date: August 10, 2017
    Applicant: The Regents of the University of California
    Inventors: Maxim Sergeev, Federica Morgia, Robert Michael Van Dam, Mark Lazari