Patents by Inventor Maxime Mickael Mahe

Maxime Mickael Mahe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making in vivo human small intestine organoids from pluripotent stem cells
    Patent number: 11584916
    Abstract: Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS).
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: February 21, 2023
    Assignee: Children's Hospital Medical Center
    Inventors: James M. Wells, Carey Lane Watson, Jorge Orlando Munera, Maxime Mickael Mahe, Michael A. Helmrath, Michael J. Workman
  • SHAPED ORGANOID COMPOSITIONS AND METHODS OF MAKING SAME
    Publication number: 20220243179
    Abstract: Disclosed herein are organoid compositions that are manipulated to form shaped or elongated morphologies that more closely resemble native organ structures. These shaped organoids are advantageous for purposes such as studying organellar organization and for transplants compared to unformed organoids. Also disclosed herein are methods of producing said shaped or elongated organoid compositions.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 4, 2022
    Inventors: Michael A. Helmrath, Maxime Mickael Mahe, Holly M. Poling
  • METHODS OF MAKING IMPROVED HUMAN INTESTINAL ORGANOID COMPOSITIONS VIA APPLICATION OF STRAIN AND HUMAN INTESTINAL ORGANOID COMPOSITIONS THEREOF
    Publication number: 20210115366
    Abstract: Disclosed herein are methods of enhancing development of a three-dimensional in vitro model of an intestinal tissue (HIO), which may be derived from a precursor cell. The precursor cell may be, for example, an embryonic stem cell, an induced pluripotent stem cell (iPSC), or the like. The in vitro HIO model may be characterized in that the HIO has a lumen, in which a lengthening device may be inserted to promote development of the HIO. Compositions derived from the disclosed methods are also described.
    Type: Application
    Filed: April 24, 2018
    Publication date: April 22, 2021
    Inventors: Maxime Mickael Mahe, Michael A. Helmrath, Holly M. Poling, James Wells
  • IN VIVO MODEL OF HUMAN SMALL INTESTINE USING PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USING SAME
    Publication number: 20170292116
    Abstract: Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS).
    Type: Application
    Filed: October 16, 2015
    Publication date: October 12, 2017
    Inventors: James M. Wells, Carey Lane Watson, Jorge Orlando Munera, Maxime Mickael Mahe, Michael A. Helmrath, Michael J. Workman