Patents by Inventor Maximilaan HUISMAN

Maximilaan HUISMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DETECTION OF GENE LOCI WITH POLYCHROMATIC CRISPR-ASSOCIATED PROTEIN 9
    Publication number: 20230134467
    Abstract: A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci.
    Type: Application
    Filed: July 6, 2022
    Publication date: May 4, 2023
    Inventors: Thoru Pederson, Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximilaan Huisman, Shaojie Zhang
  • Detection of gene loci with CRISPR arrayed repeats and/or polychromatic single guide ribonucleic acids
    Patent number: 11390908
    Abstract: A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: July 19, 2022
    Assignees: UNIVERSITY OF MASSACHUSETTS, UNIVERSITY OF CENTRAL FLORIDA FOUNDATION, INC.
    Inventors: Thoru Pederson, Hanhui Ma, Li-Chun Tu, Ardalan Naseri, Maximilaan Huisman, Shaojie Zhang
  • Detection Of Gene Loci With CRISPR Arrayed Repeats And/Or Polychromatic Single Guide Ribonucleic Acids
    Publication number: 20190249230
    Abstract: A C9orf72 DNA repeat expansion can be detected using a CRISPR Arrayed Repeat Detection System (CARDS). Based upon the compositions and methods supporting this platform primary cell cultures and/or blood cell smears can be tested under conventional clinical diagnostic laboratory conditions to diagnose genetically-based diseases having DNA repeat expansions, including but not limited to ALS. dCas9 constructs are also contemplated as having fluorescent proteins bound to any or all stem loop sequences, wherein detection of a plurality of dCas9 constructs having different colored fluorescent proteins can simultaneously detect at least six (6) different gene target loci.
    Type: Application
    Filed: September 1, 2016
    Publication date: August 15, 2019
    Inventors: Thoru PEDERSON, Hanhui MA, Li-Chun TU, Ardalan NASERI, Zuoshang XU, Maximilaan HUISMAN, Chunxing YANG, Shaojie ZHANG