Abstract: Methods for predicting the outcome of production of peptides are provided, as well as methods for producing peptides or providing products comprising peptides, which uses said methods. The methods comprise providing a primary amino acid sequence for one or more peptides, and Provide ore or more metrics predicting the outcome of production of the one or more peptides by chemical synthesis using a machine learning model that has been trained to predict one or more metrics characterising the outcome of production of peptides using training data comprising training peptide primary sequences and measured metrics characterising the outcome of production of the training peptides by chemical synthesis. The measured metrics are metrics obtained after completion of the chemical synthesis process. Systems and products for performing the methods are also described.

Abstract: The invention relates to a method of making a thin construction element (10) in sandwich lightweight construction having a high-quality surface (26). Including the steps of deep drawing a substrate film, placing the deep-drawn film into a cavity of a die, introducing partially expanded particles onto the substrate, heating to completely expanded the particle foam, curing the expanded particle foam, and opening the die to remove the molded article.

Abstract: A method of treating a subject having been diagnosed as having cancer with an immunotherapy is described. The method comprises targeting one or more clonal neoantigens selected using a method comprising determining whether a tumour-specific mutation is likely to be clonal in a subject. The method comprises providing sequence data from one or more samples from the subject comprising tumour genetic material, the sequence data comprising for each of the one or more samples, and determining the likelihood that the tumour-specific mutation is clonal as a posterior probability depending on: a prior probability of the mutation being clonal, and the probabilities of observing the sequence data if the tumour-specific mutation is (i) clonal and (ii) non-clonal, in view of a tumour fraction for each of the one or more samples and one or more candidate joint genotypes.

Abstract: The present invention provides a method for obtaining tumour nucleic acid for sequencing, comprising providing a medium containing tumour cells shed from a solid tumour sample into the medium ex vivo and/or released during mechanical disruption of a solid tumour sample and extracting nucleic acid from the shed and/or released tumour cells tumour cells.

Abstract: A method of treating a subject having been diagnosed as having cancer with an immunotherapy is described. The method comprises targeting one or more clonal neoantigens selected using a method comprising determining whether a tumour-specific mutation is likely to be clonal in a subject. The method comprises providing sequence data from one or more samples from the subject comprising tumour genetic material, the sequence data comprising for each of the one or more samples, and determining the likelihood that the tumour-specific mutation is clonal as a posterior probability depending on: a prior probability of the mutation being clonal, and the probabilities of observing the sequence data if the tumour-specific mutation is (i) clonal and (ii) non-clonal, in view of a tumour fraction for each of the one or more samples and one or more candidate joint genotypes.

Abstract: A method of treating a subject having been diagnosed as having cancer with an immunotherapy is described. The method comprises targeting one or more clonal neoantigens selected using a method comprising determining whether a tumour-specific mutation is likely to be clonal in a subject. The method comprises providing sequence data from one or more samples from the subject comprising tumour genetic material, the sequence data comprising for each of the one or more samples, and determining the likelihood that the tumour-specific mutation is clonal as a posterior probability depending on: a prior probability of the mutation being clonal, and the probabilities of observing the sequence data if the tumour-specific mutation is (i) clonal and (ii) non-clonal, in view of a tumour fraction for each of the one or more samples and one or more candidate joint genotypes.

Abstract: A metering device for the metered withdrawal of free-flowing beverages and sauces from at least one storage container, including at least one chamber having an inlet for receiving the liquid from the storage container and an outlet for dispensing the metered liquid into a vessel, wherein the metering device has at least one temperature control device that heats or cools the metered liquid, wherein the metering device has two chambers that are arranged one above the other and are connected to one another in a fluid-conducting manner by a connecting channel, and wherein a vertically displaceable push rod extends along a longitudinal axis of the housing, through the outlet, the second chamber, the connecting channel, the first chamber, and the inlet, and, depending on the vertical position, the push rod closes the outlet and/or the connecting channel in a fluid-sealing manner and actuates the closure.

Abstract: The invention relates inter alia to a method of making a thin component (10) in lightweight sandwich construction with a high-quality surface (26).

Abstract: The invention relates, inter alia, to a method of making a thin component (10) in a lightweight sandwich construction having a high-quality surface (26).

Abstract: Among other things, the invention relates to a method of making a thin construction element (10) in sandwich lightweight construction having a high-quality surface (26).