Abstract: The disclosure refers to a method, reaction chamber and system for treatment of liquids in continuous flow including the steps of receiving a liquid for treatment in a reaction chamber; converting q flow of liquid for treatment in a biphasic liquid-gas flow; directing the biphasic flow to a central section of the reaction chamber, where an electric field is applied; ionizing the gaseous fraction of the biphasic flow that passes through said central section sustaining an ionization regime generating non-thermal plasma throughout the central section of the reaction chamber leading the biphasic flow under the ionization regime to a discharge section of the reaction chamber, where the electric field is applied, generating the deionization of the gaseous fraction and causing the biphasic flow to reduce its velocity, which results in the condensation of biphasic flow; and removing a flow of treated liquid from said discharge section.