Patents by Inventor Maximillian A. Rogers

Maximillian A. Rogers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating Niemann-Pick type C disease
    Patent number: 9206425
    Abstract: The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of Niemann-Pick Type C disease and prolong survival of patients with the disease, either alone or in combination with other treatments.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: December 8, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Maximillian A. Rogers
  • Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease
    Patent number: 9149492
    Abstract: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: October 6, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Yohei Shibuya, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers
  • Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease
    Patent number: 8802646
    Abstract: The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: August 12, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers
  • METHODS FOR TREATING NIEMANN-PICK TYPE C DISEASE
    Publication number: 20140220114
    Abstract: The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are used to treat symptoms of Niemann-Pick Type C disease and prolong survival of patients with the disease, either alone or in combination with other treatments.
    Type: Application
    Filed: July 24, 2012
    Publication date: August 7, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Maximillian A. Rogers
  • METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE
    Publication number: 20140044757
    Abstract: The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the expression or activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
    Type: Application
    Filed: September 11, 2013
    Publication date: February 13, 2014
    Applicant: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang, Yohei Shibuya, Elena Bryleva, Stephanie Murphy, Maximillian A. Rogers