Patents by Inventor Maxine Linial

Maxine Linial has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Foamy virus mutant reverse transcriptase
    Patent number: 7560117
    Abstract: The present invention relates to a highly processive reverse transcriptase having DNA polymerase activity and substantially reduced protease activity. More specifically, the invention relates to an isolated reverse transcriptase from foamy virus comprising a substantially inactivated protease. The invention also relates to vectors containing the gene and hosts transformed with the vector of the invention. Further, the invention relates to a method for producing reverse transcriptase having DNA polymerase activity and substantially reduced protease activity by expressing the reverse transcriptase genes of the present invention in a recombinant host. Methods are also provided for producing cDNA from polynucleotides using the highly processive reverse transcriptase of the invention. Kits for the preparation of cDNA from RNA comprising the highly processive reverse transcriptase of the invention are also provided.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: July 14, 2009
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Stephen Hughes, Paul Boyer, Maxine Linial, Carolyn Stenbak, Patrick Clark
  • Foamy virus mutant reverse transcriptase
    Publication number: 20040132009
    Abstract: The present invention relates to a highly processive reverse transcriptase having DNA polymerase activity and substantially reduced protease activity. More specifically, the invention relates to an isolated reverse transcriptase from foamy virus comprising a substantially inactivated protease. The invention also relates to vectors containing the gene and hosts transformed with the vector of the invention. Further, the invention relates to a method for producing reverse transcriptase having DNA polymerase activity and substantially reduced protease activity by expressing the reverse transcriptase genes of the present invention in a recombinant host. Methods are also provided for producing cDNA from polynucleotides using the highly processive reverse transcriptase of the invention. Kits for the preparation of cDNA from RNA comprising the highly processive reverse transcriptase of the invention are also provided.
    Type: Application
    Filed: November 21, 2003
    Publication date: July 8, 2004
    Inventors: Stephen Hughes, Paul Boyer, Maxine Linial, Carolyn Rinke, Patrick Clark