Abstract: The present invention relates to systems and methods for improvement of physiological function in an individual with a spinal cord injury via electrical stimulation of the spinal cord. A 3D model of the spinal cord is used to determine an initial position for an electrode array to deliver stimulation. Spinal cord electrical stimulation is configurable to target different physiological functions with surgical implantation of the neurostimulator at a singular location. Such systems and methods include (i) anatomical specificity to target the appropriate region of the spinal cord for stimulation, (ii) electrical specificity to provide the appropriate stimulation by delivery method, frequency, pulse duration, and other factors, and (iii) physiological specificity to evoke, suppress, increase, or decrease a specific physiological result.

Abstract: Methods for optimization of surgical placement of an implantable electrode for spinal cord epidural stimulation of a subject include creating a computational model of the subject spinal cord based on medical imagery, determining the position of the lumbosacral enlargement, and determining an optimal placement to maximize volumetric coverage of the lumbosacral enlargement by the implantable electrode.

Abstract: Provided are bone quality and/or strength measuring devices. In some embodiments, the devices include a body and a detector disposed therein designed to interact with a bone, determine the quality and/or strength thereof, and communicate an evaluation thereof to a user. The presently disclosed devices can also include a torque and/or force sensor that facilitates placement of the device and/or that is in communication with the detector to cause the detector to evaluate the bone; an output that feedback to a user based on the quality and/or strength of the bone determined by the detector, and/or a piston that interacts with the detector to cause the detector to interact with and thereby evaluate the bone. Also provided are methods for determining if a region of a bone is appropriate for placement of an orthopedic hardware piece and methods for reducing risk of a complication of spinal surgery associated with failure of an orthopedic hardware piece.