Abstract: A system and method is provided for probabilistic defense against remote exploitation of memory. In certain embodiments, the system comprises one or more processors, read and execute (RX) portions of memory, read and write (RW) portions of memory, execute only (XOM) portions of memory, and one or more programs stored in the memory. The one or more programs include instructions for maintaining all pointers to RX memory instructions in XOM memory. In addition, the one or more programs include instructions for preventing all direct references to RX memory in RW memory by forcing pointers in RW memory to reference XOM memory first, which then references RX memory instructions.