Patents by Inventor May D. Lee

May D. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotics from microbispora
    Patent number: 6551591
    Abstract: The present invention provides a novel strain of Microbispora corallina, means for identifying it, methods for culturing it at several different levels, two new antibiotics derived from the cultures and the physico-chemical characteristics of those compounds and their biological activity against a variety of microorganisms.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: April 22, 2003
    Assignee: Essential Therapeutics, Inc.
    Inventor: May D. Lee
  • Production of high titers of gibberellins, GA4 and GA7, by Gibberella fujikuroi strain LTB-1027
    Patent number: 6287800
    Abstract: A new method of producing a mixture of gibberellins which is predominantly GA4 and GA7 but also contains GA3 has the steps of providing a seed of Gibberella fujikuroi Strain LTB-1027 or mutants derived therefrom, inoculating the seed into a culture medium rich in carbohydrate and relatively low in nitrogen, incubating the culture for at least four days, separating the Gibberella fujikuroi Strain LTB-1027 from the culture broth, and extracting the gibberellins to produce a gibberellin mixture which is at least 50% GA4 and GA7. The method produces a gibberellin mixture in which the combined titer of GA4 and GA7 exceeds 800 mg/liter. The production method also produces a gibberellin mixture with approximately equal titers of gibberellins GA4 and GA7. A variation of the method produces a gibberellin mixture which contains over 40% GA4.
    Type: Grant
    Filed: August 23, 2000
    Date of Patent: September 11, 2001
    Inventors: Jorge L. Gallazzo, May D. Lee
  • Antibiotic LL-14E605.beta. and O-methyl-LL-14E605.beta.
    Patent number: 5451581
    Abstract: This invention relates to the antibiotics LL-14E605.beta. and O-methyl-LL-14E605.beta. derived from the microorganism Sebekia benihana which are useful as antibacterial agents.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: September 19, 1995
    Inventors: May D. Lee, Peter T. Northcote, Mary Lechevalier
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 5108912
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora spp. calichensis NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 28, 1992
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Dihydro derivatives of LL-E33288 antibiotics
    Patent number: 5037651
    Abstract: Dihydro derivatives of LL-E33288, BBM-1075 FR-900405, FR-900406, PD 114759, PD 115028, CL-1577A, CL-1577B, CL-1577D, CL-1577E and CL-1724 antibiotics/antitumor agents are disclosed and described, including the degradation product of LL-E33288 antibiotics/antitumor agents dihydro-LL-E33288-pseudoaglycone.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: August 6, 1991
    Assignee: American Cyanamid Company
    Inventor: May D. Lee
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 4970198
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: November 13, 1990
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Antibiotic LL-C19004
    Patent number: 4870019
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Antibiotic LL-C19004
    Patent number: 4699790
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: October 13, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Antibiotic agents from S. coeruleorubidus, rubidus
    Patent number: 4677071
    Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
    Type: Grant
    Filed: August 6, 1984
    Date of Patent: June 30, 1987
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa
  • Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega..sub.1, LL-D49194.omega..sub.2, and LL-D49194.omega..sub.3
    Patent number: 4626503
    Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Amedeo A. Fantini, David P. Labeda, William M. Maiese, Raymond T. Testa, Donald B. Borders
  • Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp. nov.
    Patent number: 4568646
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-D05139 .beta.
    Patent number: 4503044
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: March 5, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic agents from S. coeruleorubidus, rubidus
    Patent number: 4499075
    Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: February 12, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa