Abstract: A method of evaluating treatment of subject with an IL23 antibody and treating psoriatic arthritis in the subject by measuring the indices DAPSA low disease activity (LDA) and Investigator Global Assessment (IGA) of psoriasis and adjusting or maintaining dose and dosage intervals in administering an IL23 antibody, e.g., guselkumab, to the subject.

Abstract: A method of treating psoriatic arthritis in a patient having showed an inadequate response to treatment with an anti-TNF therapy by administering an IL-23 specific antibody, e.g., guselkumab, in a clinically proven safe and clinically proven effective amount and the patient achieves significant ACR20/50/70, IGA, HAQ-DI, CRP, SF-36 PCS/MCS, MDA, VLDA, enthesitis, dactylitis, and LEI/dactylitis improvement as measured 16, 24 and 48 weeks after initial treatment.

Abstract: A system and method which allow for connecting users with people of interest based on preferences and current location. The system allows users to connect when on board of the same transportation means such as an airplane. A wireless network is provided which is connected to a server including profile information of different users. The server makes the profile of a given user available for viewing by others depending on a number of factors including the current preferences of the given user (whether they allow other users to contact them or not at the given moment) and/or depending on the presence of a match between the profiles and preferences of the users. Using the current system, users may chat in real time using mobile phones over the wireless network. A method is also described which allow for managing and securing the access of one user to another based on each user's current location.