Abstract: This application describes bivalent covalent glue mimics (CGMs). More particularly, the present application relates to protein-binding molecules that induce the formation of stable ternary complexes via covalent binding to two proteins (i.e. selective chemical crosslinking), and methods of making and uses thereof. Accordingly, included is a compound of Formula (I), Formula (II) or Formula (III) or a pharmaceutically acceptable salt and/or solvate thereof, or a composition comprising the same.