Abstract: A system and method for automated characterization of solid tumors using medical imaging. The system comprises an interface that is configured to acquire data from medical imaging devices, one or more processors, and an outputting device that reports the characterization of said solid tumor. The method of automated characterization, which is implemented by the system, acquires a sequence of images from the medical imager using a Dynamic Contrast Enhanced (DCE) imaging protocol, performs image registration, detects the contour of the solid tumor, and dividing the contours to segments. For each segment, the method calculating a displacement of the contrast material, fitting the displacement to a flow model and extracting an estimation of the interstitial fluid velocity.

Abstract: A system and method for automated characterization of solid tumors using medical imaging. The system comprises an interface that is configured to acquire data from medical imaging devices, one or more processors, and an outputting device that reports the characterization of said solid tumor. The method of automated characterization, which is implemented by the system, acquires a sequence of images from the medical imager using a Dynamic Contrast Enhanced (DCE) imaging protocol, performs image registration, detects the contour of the solid tumor, and dividing the contours to segments. For each segment, the method calculating a displacement of the contrast material, fitting the displacement to a flow model and extracting an estimation of the interstitial fluid velocity.

Abstract: Methods of expressing a recombinant polypeptide of interest are provided. Accordingly there is provided a method comprising providing a cell having been contacted with an agent which downregulates an expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and contacting the cell with a polynucleotide encoding the recombinant polypeptide of interest. Also provided is a method comprising contacting a cell with an agent which downregulates expression of a tuberous sclerosis (TSC) protein or directly inhibits an activity of same; and a polynucleotide encoding the recombinant polypeptide of interest. Also provided are isolated cells, cell cultures and articles of manufacture for recombinant expression of a recombinant polypeptide of interest.