Abstract: Systems and methods are described for modulating blood flow through a blood vessel. The systems may include one or more implantable devices including a stent frame positionable within the blood vessel, the stent frame having a substantially oval cross-sectional shape, and a valve defining an inflow end and an outflow end. The inflow end may be coupled to the stent frame and the outflow end defining an aperture and the valve may include at least one leaflet at the outflow end. The at least one leaflet may be positionable to overlay at least a portion of the aperture and configured to move in a radial direction that is perpendicular to a central axis of the stent frame.

Abstract: Coverings and/or skirts for prosthetic heart valves are disclosed. As an example, a prosthetic heart valve comprises a frame comprising three axially extending commissure support portions, a plurality of rows of angled struts including a first row defining an inflow end, a second row downstream of the first row, and a third row downstream of the second row and defining an outflow end, where downstream ends of the struts of the second row are connected to each other at junctions, and the commissure support portions extend from respective junctions to the third row of struts. The valve further comprises leaflets forming three commissures secured to respective commissure support portions, and an outer skirt comprising an outflow edge forming three circumferentially spaced projections aligned with the commissure support portions and covering respective junctions, the outflow edge comprising straight sections extending between adjacent projections upstream of the junctions.