Abstract: A method of categorizing single mode optical fibers, the method including determining one or more fiber properties of an optical fiber, the optical fiber being a single mode optical fiber at an operating wavelength of about 1310 nm. The method further including calculating a peak bandwidth wavelength of the optical fiber based on the one or more fiber properties, comparing the calculated peak bandwidth wavelength with a target peak bandwidth wavelength and based on the comparison, determining if the optical fiber meets a target modal bandwidth.

Abstract: A method of manufacturing a multimode optical fiber includes specifying a peak wavelength ?P for the multimode optical fiber. The peak wavelength ?P corresponds to a wavelength at which the multimode optical fiber has a maximum bandwidth. The multimode optical fiber comprises a core and a cladding surrounding and directly adjacent to the core. The core has a radius r1 and a maximum relative refractive index ?1,MAX>0. The cladding comprises a depressed-index region having a minimum relative refractive index ?3,MIN<0 and a volume v. A draw tension T for the multimode optical fiber is selected based on a correlation relating peak wavelength ?P to draw tension T, the correlation comprising a correlation constant. The correlation constant K is a function of at least one of ?1,MAX, r1, v, ?3,MIN, and ?P. The multimode optical fiber is drawn from a preform at the draw tension T.

Abstract: A method of categorizing a group of multimode optical fibers, the method including comparing an effective modal bandwidth of a first multimode optical fiber with a first threshold, the first multimode optical fiber being in a group of multimode optical fibers meeting a first OM-standard and the first threshold being an effective modal bandwidth of the first multimode optical fiber. The method further including categorizing the first multimode optical fiber as meeting OM functional requirements of a second OM-standard if the effective modal bandwidth of the first multimode optical fiber is equal to or above the first threshold, wherein the second OM-standard is higher than the first OM-standard.

Abstract: Methods for classifying a core cane of an multimode optical fiber are disclosed. In embodiments, the method includes determining a relative refractive index profile ?(r) of the core cane; fitting the relative refractive index profile ?(r) to an alpha profile ?fit(r) defined by: ? fit ( r ) = ? o , fit ( 1 - ( r a fit ) ? fit ) where ?o,fit is a relative refractive index at a longitudinal centerline of the core cane, ?fit is a core shape parameter, and afit is an outer radius of the core cane; generating a non-alpha residual profile ?diff(r)=?(r)??fit(r) for the core cane; computing one or more metrics from ?diff(r), and using the one or metrics in a classification of the core cane, the classification comprising a prediction of whether a bandwidth at a pre-determined wavelength of an optical fiber drawn from a preform comprising the core cane exceeds a pre-determined bandwidth at the pre-determined wavelength.

Abstract: A method of manufacturing a tuned optical fiber includes providing a first preform from a set of like preforms each having substantially the same refractive index profile, including amount of axial variation relative to a target refractive index profile. The method includes drawing a reference optical fiber from the first preform and measuring a variation in an optical or physical property as a function of axial position. The method also includes drawing from a second preform from the set of like preforms the tuned optical fiber. The drawing includes using a time-varying tension that reduces the amount of variation of the optical or physical property of interest. The time-varying tension is defined by an amount of axial stress imparted to the tuned fiber needed to alter the refractive index profile and the at least one optical or physical property based on a stress-optic effect.

Abstract: A multimode optical fiber having a core region. The core region includes silica, has an outer radius r1, and has a maximum relative refractive index of about 1.5% or less. Additionally, the multimode optical fiber is configured to have an effective bandwidth of about 4.7 GHz-Km or greater for an excited portion of the core region that has a diameter greater than 50 microns, the effective bandwidth being at a wavelength that is within a range of between about 800 and about 1370 nm.

Abstract: A multimode optical fiber having a core region. The core region includes silica, has an outer radius r1, and has a maximum relative refractive index of about 1.5% or less. Additionally, the multimode optical fiber is configured to have an effective bandwidth of about 4.7 GHz-Km or greater for an excited portion of the core region that has a diameter greater than 50 microns, the effective bandwidth being at a wavelength that is within a range of between about 800 and about 1370 nm.

Abstract: A method of manufacturing a multimode optical fiber includes specifying a peak wavelength ?P for the multimode optical fiber. The peak wavelength ?P corresponds to a wavelength at which the multimode optical fiber has a maximum bandwidth. The multimode optical fiber comprises a core and a cladding surrounding and directly adjacent to the core. The core has a radius r1 and a maximum relative refractive index ?1,MAX>0. The cladding comprises a depressed-index region having a minimum relative refractive index ?3,MIN<0 and a volume v. A draw tension T for the multimode optical fiber is selected based on a correlation relating peak wavelength ?P to draw tension T, the correlation comprising a correlation constant. The correlation constant K is a function of at least one of ?1,MAX, r1, v, ?3,MIN, and ?P. The multimode optical fiber is drawn from a preform at the draw tension T.

Abstract: The present disclosure includes high concentration, low viscosity pharmaceutical formulations that include an anti-C5 antibody or antigen-binding fragment thereof and arginine. Such formulations may be provided in association with an RNAi molecule such as cemdisiran. Methods of treating C5-associated diseases such as PNH and aHUS are also provided.

Abstract: A method of manufacturing a tuned optical fiber includes providing a first preform from a set of like preforms each having substantially the same refractive index profile, including amount of axial variation relative to a target refractive index profile. The method includes drawing a reference optical fiber from the first preform and measuring a variation in an optical or physical property as a function of axial position. The method also includes drawing from a second preform from the set of like preforms the tuned optical fiber. The drawing includes using a time-varying tension that reduces the amount of variation of the optical or physical property of interest. The time-varying tension is defined by an amount of axial stress imparted to the tuned fiber needed to alter the refractive index profile and the at least one optical or physical property based on a stress-optic effect.

Abstract: An apparatus is provided which comprises: a chassis compartment having a bottom surface and walls orthogonal to the bottom, wherein the chassis compartment comprises: a rectangular opening, which may be designed to accept a microelectromechanical (MEMS) device and four slots, which may be designed to accept one or more magnet(s), extending outwardly from the rectangular opening, wherein each of the slots comprises: an inner opening having a length coextensive with a side of the rectangular opening, and an outer opening having corresponding ends that extend a length of the outer opening beyond the length of the inner opening. Other embodiments are also disclosed and claimed.

Abstract: Biopharmaceutical compositions and drug products disclosed herein exhibit reduced amounts of subvisible particle formation. Compositions and drug products disclosed herein comprise a protein and a surfactant or stabilizer including high percentage amounts (e.g., at least 97%) of a long-chain fatty acid ester. Also disclosed herein are methods of preparing and storing such compositions and drug products.

Abstract: An apparatus is provided which comprises: a chassis compartment having a bottom surface and walls orthogonal to the bottom, wherein the chassis compartment comprises: a rectangular opening, which may be designed to accept a microelectromechanical (MEMS) device and four slots, which may be designed to accept one or more magnet(s), extending outwardly from the rectangular opening, wherein each of the slots comprises: an inner opening having a length coextensive with a side of the rectangular opening, and an outer opening having corresponding ends that extend a length of the outer opening beyond the length of the inner opening. Other embodiments are also disclosed and claimed.

Abstract: An optical fiber including a multimode core having a radius, R1, and a maximum relative refractive index, ?1MAX, at a wavelength ?0, an inner clad layer surrounding the core and having a radial thickness, T2, and a minimum relative refractive index, ?2MIN, of about 0.0% at a wavelength of ?0, an intermediate clad layer surrounding the inner clad layer and having a radial thickness, T3, and a maximum relative refractive index ?3MAX and an outer clad layer surrounding the inner clad layer and having a radial thickness, T4, and a maximum relative refractive index, ?4MIN, at a wavelength of ?0. The optical fiber satisfies the following relationship: ?1MAX>?3MAX>?2MIN, and the optical fiber exhibits an overfilled bandwidth of greater than or equal to about 1.5 GHz-km at ?0.

Abstract: An optical fiber including a multimode core having a radius, R1, and a maximum relative refractive index, ?1MAX, at a wavelength ?0, an inner clad layer surrounding the core and having a radial thickness, T2, and a minimum relative refractive index, ?2MIN, of about 0.0% at a wavelength of ?0, an intermediate clad layer surrounding the inner clad layer and having a radial thickness, T3, and a maximum relative refractive index ?3MAX and an outer clad layer surrounding the inner clad layer and having a radial thickness, T4, and a maximum relative refractive index, ?4MIN, at a wavelength of ?0. The optical fiber satisfies the following relationship: ?1MAX>?3MAX>?2MIN, and the optical fiber exhibits an overfilled bandwidth of greater than or equal to about 1.5 GHz-km at ?0.

Abstract: A device and method are described for the delivery of cells, tissues, enzymes and/or pharmacological agents for the treatment or prevention of diseases, disorders or deficiencies. The device is placed intravascularly and includes a chamber that houses living cells delimited by a membrane on either side that physically separates the cells from the blood stream and the central lumen of the catheter. The device can be inserted over a guidewire and permits flushing and reloading of the central lumen with viability supporting factors that sustain the cells in the outer chamber for long indwelling times without removing it from the body. In addition, the central lumen can be used to deliver therapeutic substances or withdraw blood.