Patents by Inventor Mayda Gursel

Mayda Gursel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 9163244
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: October 20, 2015
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20140134233
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: September 13, 2013
    Publication date: May 15, 2014
    Applicant: The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 8580944
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: November 12, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Method of treating inflammatory arthropathies with supressors of CPG oligonucleotides
    Patent number: 8557789
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 15, 2013
    Assignee: The United States of America as represented by the Secretary of the Development of Health and Human Services
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Methods of altering an immune response induced by CpG oligodeoxynucleotides
    Patent number: 8470342
    Abstract: It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
    Type: Grant
    Filed: January 12, 2011
    Date of Patent: June 25, 2013
    Assignee: The United States of America, as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Mayda Gursel, Ihsan Gursel
  • METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES
    Publication number: 20130018089
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
    Patent number: 8288359
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: October 16, 2012
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20120258144
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: June 21, 2012
    Publication date: October 11, 2012
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 8227438
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: July 24, 2012
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 8227446
    Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5?X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: July 24, 2012
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
  • OLIGODEOXYNUCLEOTIDE AND ITS USE TO INDUCE AN IMMUNE RESPONSE
    Publication number: 20110212135
    Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5?X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
    Type: Application
    Filed: May 10, 2011
    Publication date: September 1, 2011
    Applicant: The Gov't of USA as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
  • METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES
    Publication number: 20110201676
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: April 25, 2011
    Publication date: August 18, 2011
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Method for rapid generation of mature dendritic cells
    Patent number: 7959934
    Abstract: Novel methods of rapidly generating dendrtic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one specific, non-limiting example, the method includes contacting the dendritic cell precursor or the mature dendritic cell with an antigen. The methods are of use both in vitro and in vivo.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: June 14, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Mayda Gursel, Daniela Verthelyi
  • Oligodeoxynucleotide and its use to induce an immune response
    Patent number: 7960356
    Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5? X1X2X3Pu1 Py2 CpG Pu3 Py4 X4X5X6(W)M (G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: June 14, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Dennis Klinman, Daniela Verthelyi, Ken Ishii, James J. Mond, Mayda Gursel
  • Method of treating inflammatory arthropathies with suppressors of CpG oligonucleotides
    Patent number: 7951786
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: May 31, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY CPG OLIGODEOXYNUCLEOTIDES
    Publication number: 20110110883
    Abstract: It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
    Type: Application
    Filed: January 12, 2011
    Publication date: May 12, 2011
    Inventors: Dennis M. Klinman, Mayda Gursel, Ihsan Gursel
  • Methods of altering an immune response induced by CpG oligodeoxynucleotides
    Patent number: 7892569
    Abstract: It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 22, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Mayda Gursel, Ihsan Gursel
  • SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE
    Publication number: 20090208468
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: February 27, 2009
    Publication date: August 20, 2009
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi
  • METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES
    Publication number: 20090142310
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Application
    Filed: November 28, 2008
    Publication date: June 4, 2009
    Inventors: Dennis Klinman, Rainald Zeuner, Daniela Verthelyi, Ihsan Gursel, Mayda Gursel
  • Suppressors of CpG oligonucleotides and methods of use
    Patent number: 7514414
    Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: April 7, 2009
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Dennis M. Klinman, Rainald Zeuner, Mayda Gursel, Ihsan Gursel, Daniela Verthelyi