Abstract: Disclosed herein is a novel technique that employs non-invasive ultrasound for spatiotemporal modulation of the refractive index in a medium to define and control the trajectory of light within the medium itself, thereby creating a virtual sculpted lens. By varying the amplitude of ultrasonic waves in the medium, the numerical aperture (NA) value of the virtual sculpted lens can be changed. The location of the focus of the virtual sculpted lens can be precisely scanned within a scattering tissue.

Abstract: Disclosed herein is a fully flexible photonic platform based on a high density, flexible array of ultra-compact optical waveguides composed of biocompatible polymers Parylene C and PDMS. The photonic platform features unique embedded input/output micro-mirrors that redirect light from the waveguides perpendicularly to the surface of the array for localized, patterned illumination in tissue. This architecture enables the design of a fully flexible, compact integrated photonic system to realize an implantable, wearable or on-chip photonic platform for application such as in vivo chronic optogenetic stimulation of brain activity.

Abstract: Disclosed here are two approaches for implementing neural probes that consist of a thin, high-density Parylene C-based probe on a stainless steel shuttle. In a first approach, the high density Parylene C probe is microfabricated separately and is then affixed to a planar or curved stainless steel shuttle. In a second approach, the high-density probe is monolithically fabricated on a stainless steel shuttle by micromachining the stainless steel substrate.

Abstract: Disclosed herein is a novel reconfigurable spatial and temporal light modulation method that exploits the imaging medium itself by employing a multi-element ultrasonic transducer array as an in-situ acoustic modulator. The medium density can be modulated using different ultrasonic pressure patterns to pattern an incident collimated beam of light.

Abstract: Disclosed herein is a novel technique that employs non-invasive ultrasound for spatiotemporal modulation of the refractive index in a medium to define and control the trajectory of light within the medium itself, thereby creating a virtual sculpted lens. By varying the amplitude of ultrasonic waves in the medium, the numerical aperture (NA) value of the virtual sculpted lens can be changed. The location of the focus of the virtual sculpted lens can be precisely scanned within a scattering tissue.

Abstract: Disclosed herein is a novel reconfigurable spatial and temporal light modulation method that exploits the imaging medium itself by employing a multi-element ultrasonic transducer array as an in-situ acoustic modulator. The medium density can be modulated using different ultrasonic pressure patterns to pattern an incident collimated beam of light.

Abstract: Devices for producing localized surface plasmon resonances are described having a plasmonic resonator and a photonic structure electromagnetically coupled to the plasmonic resonator. The device can include a hybrid photonic plasmonic resonator that contains plasmonic and photonic resonators, and are optionally coupled to a photonic waveguide, or a plasmonic resonator coupled directly to a photonic waveguide. The plasmonic resonator can be one or more nanoparticles. The devices can produce substantial increases in coupling efficiencies and sensitivity for use in several applications, including SERS and refractive index sensing.