Patents by Inventor Mayuri SHARMA

Mayuri SHARMA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CHARACTERIZING THE IMMUNE RESPONSE OF A SUBJECT TO A DENGUE VIRUS COMPOSITION
    Publication number: 20240142451
    Abstract: The present invention relates to a method for characterizing the immune response of a subject to a tetravalent dengue virus composition by performing the method for determining affinity, binding kinetics and/or concentration of an antibody or of an antibody mixture and at least one other method. In a further embodiment, the present invention relates to a method for characterizing the immune response of a subject to a virus-containing vaccine composition by performing a combination of assays. In a further embodiment, the present invention relates to a method for predicting protective efficacy of a dengue vaccine candidate. In another embodiment the present invention relates to a method for preparing a vaccine formulation.
    Type: Application
    Filed: March 31, 2022
    Publication date: May 2, 2024
    Inventors: Isamu TSUJI, Hansi DEAN, Mayuri SHARMA, Christina DEMASO, Michael EGAN, Eduardo NASCIMENTO
  • Zika viral antigen constructs
    Patent number: 11780885
    Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: October 10, 2023
    Assignees: GLAXOSMITHKLINE BIOLOGICALS SA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Kimberly Dowd, Barney S. Graham, Sung-Youl Ko, Wing-Pui Kong, John Mascola, Theodore Pierson, Mayuri Sharma, Dong Yu
  • ZIKA VIRAL ANTIGEN CONSTRUCTS
    Publication number: 20230242593
    Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.
    Type: Application
    Filed: September 16, 2022
    Publication date: August 3, 2023
    Applicants: GLAXOSMITHKLINE BIOLOGICALS SA, THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: KIMBERLY DOWD, BARNEY S. GRAHAM, SUNG-YOUL KO, WING-PUI KONG, JOHN MASCOLA, THEODORE PIERSON, MAYURI SHARMA, DONG YU
  • Zika viral antigen constructs
    Patent number: 10967057
    Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen. A particular embodiment is a nucleic acid-based vaccine construct encoding a polypeptide comprising a full-length Zika virus prME antigen. A particular embodiment is a self-replicating RNA molecule comprising a construct encoding a polypeptide comprising a full-length Zika virus prME antigen.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: April 6, 2021
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Dong Yu, Mayuri Sharma
  • ZIKA VIRAL ANTIGEN CONSTRUCTS
    Publication number: 20190345205
    Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.
    Type: Application
    Filed: November 15, 2017
    Publication date: November 14, 2019
    Applicants: GLAXOSMITHKLINE BIOLOGICALS, S.A., The United States of America, as Represented by the Department of Health and Human Services
    Inventors: Kimberly DOWD, Barney S. GRAHAM, Sung-Youl KO, Wing-Pui KONG, John MASCOLA, Theodore PIERSON, Mayuri SHARMA, Dong Yu
  • ZIKA VIRAL ANTIGEN CONSTRUCTS
    Publication number: 20190134184
    Abstract: Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen. A particular embodiment is a nucleic acid-based vaccine construct encoding a polypeptide comprising a full-length Zika virus prME antigen. A particular embodiment is a self-replicating RNA molecule comprising a construct encoding a polypeptide comprising a full-length Zika virus prME antigen.
    Type: Application
    Filed: June 1, 2017
    Publication date: May 9, 2019
    Inventors: Dong YU, Mayuri SHARMA