Patents by Inventor Md. Jashim Uddin

Md. Jashim Uddin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-COX-2 NANOBODIES FOR ENDOSCOPIC VISUALIZATION OF COLORECTAL ADENOMAS
    Publication number: 20250242062
    Abstract: Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality in men and women. Uncontrolled proliferation of CRC cells is pivotal in colorectal tumorigenesis and cyclooxygenase-2 (COX-2) is an important regulatory enzyme in this process. Timely diagnosis is the key to life-saving management of CRC, which is under-diagnosed because colorectal aberrant crypt foci, hyper plastic polyps, micro edemas are often missed with conventional colonoscopy. Disclosed herein are imaging agents tagged to nanobodies specific for COX-2 protein that can selectively accumulate and retain in COX-2 expressing cells and colorectal adenomas, resulting in specific and sensitive of early detection, while reducing background and off-target systemic toxicity. The prospect of combining structural and functional imaging readouts obtained with fluorescence-aided colonoscopy measurements would provide powerful diagnostic information for improved management of colorectal carcinogenesis.
    Type: Application
    Filed: March 30, 2023
    Publication date: July 31, 2025
    Inventors: Md. Jashim UDDIN, Shu XU, Ansari M. Aleem, Brian E. WADZINSKI, Benjamin W. SPILLER, Lawrence J. MARNETT, Michael Christopher GOODMAN
  • Methods and compositions for diagnostic and therapeutic targeting of COX-2
    Patent number: 8865130
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: October 21, 2014
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
  • METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2
    Publication number: 20130052138
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Application
    Filed: March 27, 2012
    Publication date: February 28, 2013
    Applicant: Vanderbilt University
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
  • Methods and compositions for diagnostic and therapeutic targeting of COX-2
    Patent number: 8143302
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: March 27, 2012
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
  • METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2
    Publication number: 20100254910
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Application
    Filed: June 11, 2010
    Publication date: October 7, 2010
    Applicant: Vanderbilt University
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews
  • Methods and compositions for diagnostic and therapeutic targeting of COX-2
    Patent number: 7736624
    Abstract: The presently disclosed subject matter provides compositions that selectively bind cyclooxygenase-2 and comprise a therapeutic and/or diagnostic moiety. Also provided are methods for using the disclosed compositions for diagnosing (i.e., by imaging) a target cell and/or treating a disorder associated with a cyclooxygenase-2 biological activity.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: June 15, 2010
    Inventors: Lawrence J. Marnett, Md. Jashim Uddin, Brenda C. Crews