Patents by Inventor Meaghan Anne O'Reilly

Meaghan Anne O'Reilly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230255597
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: September 6, 2022
    Publication date: August 17, 2023
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Patent number: 11464482
    Abstract: A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: October 11, 2022
    Assignee: Sunnybrook Research Institute
    Inventors: Kullervo Henrik Hynynen, Meaghan Anne O'Reilly
  • Patent number: 11432802
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: September 6, 2022
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Publication number: 20200330075
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 22, 2020
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Patent number: 10702244
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: July 7, 2020
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Publication number: 20160007954
    Abstract: A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Inventors: Kullervo Henrik HYNYNEN, Meaghan Anne O'REILLY
  • Publication number: 20130006106
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen