Patents by Inventor Mechelle Lesher

Mechelle Lesher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for stable transduction of cells with viral vectors
    Publication number: 20040062756
    Abstract: The present invention provides methods, as well as compositions related thereto, for the efficient transduction of cells using viral vectors. The efficiency of transduction is increased by contacting the cell to be transduced with one or more molecules that bind the cell surface. Contact with a cell surface binding molecule may occur before, after, or simultaneously with contact between the viral vector and the cell. The transduced vectors may be constructed to express a gene of interest, permitting the transduced cells to be used as therapeutic and prophylactic agents.
    Type: Application
    Filed: September 16, 2003
    Publication date: April 1, 2004
    Inventors: Laurent Humeau, Wei Han, Xiaobin Lu, Vladimir Slepushkin, Mechelle Lesher, Brian Davis, Yung-Nien Chang, Boro Dropulic
  • Methods for stable transduction of cells with hiv-derived viral vectors
    Patent number: 6627442
    Abstract: The present invention provides methods, as well as compositions related thereto, for the efficient transduction of cells using viral vectors. The efficiency of transduction is increased by contacting the cell to be transduced with one or more molecules that bind the cell surface. Contact with a cell surface binding molecule may occur before, after, or simultaneously with contact between the viral vector and the cell. The transduced vectors may be constructed to express a gene of interest, permitting the transduced cells to be used as therapeutic and prophylactic agents.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: September 30, 2003
    Assignee: VIRxSYS Corporation
    Inventors: Laurent Humeau, Wei Han, Xiaobin Lu, Vladimir Slepushkin, Mechelle Lesher, Brian Davis, Yung-Nien Chang, Boro Dropulic