Patents by Inventor Mecheril Valsan Nandakumar

Mecheril Valsan Nandakumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of dimethyl fumarate
    Patent number: 10626076
    Abstract: The present invention describes an improved process for the industrial scale production of dimethyl fumarate. The process involves a one-pot ring opening reaction of maleic anhydride to monomethyl maleate and isomerization into the corresponding monomethyl fumarate in presence of a Lewis acid. Finally the mono methyl fumarate was converted into the dimethyl fumarate by an acid catalyzed esterification reaction.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: April 21, 2020
    Assignee: BIOPHORE INDIA PHARMAEUTICALS PVT. LTD.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Nagarapu Radha
  • Process for the synthesis of Dabigatran Etexilate and its intermediates
    Patent number: 10077251
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: September 18, 2018
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Process for the Synthesis of Melphalan and the Hydrochloride Salt
    Publication number: 20180237377
    Abstract: The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
    Type: Application
    Filed: April 24, 2018
    Publication date: August 23, 2018
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Madhava Reddy Vedururi, Sreenu Samireddi
  • Process for the synthesis of melphalan and the hydrochloride salt
    Patent number: 9963422
    Abstract: The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: May 8, 2018
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar, Madhava Reddy Vedururi, Sreenu Samireddi
  • Polymorph of regadenoson
    Patent number: 9624258
    Abstract: The invention provides a novel polymorph of Regadenoson. More particularly, the invention provides propylene glycol solvate of Regadenoson. The invention also provides a process for the preparation of propylene glycol solvate of Regadenoson.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: April 18, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Jagadeesh Babu Rangisetty, Manik Reddy Pullagurla, Mecheril Valsan Nandakumar, Dokula Neelam Naidu
  • Process for the preparation of (1-{9-[(4S, 2R, 3R, 5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide
    Patent number: 9580457
    Abstract: The present invention relates to a novel process for the preparation of (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: February 28, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Process for the Synthesis of Dabigatran Etexilate and Its Intermediates
    Publication number: 20170050948
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Application
    Filed: October 12, 2016
    Publication date: February 23, 2017
    Inventors: Manik Reddy PULLAGURLA, Jagadeesh Babu RANGISETTY, Mecheril Valsan NANDAKUMAR
  • Process for the synthesis of dabigatran and its intermediates
    Patent number: 9533971
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-VII) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: January 3, 2017
    Assignee: Biophore India Pharmaceuticals PVT. Ltd
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar
  • Novel Polymorph of Regadenoson
    Publication number: 20160115191
    Abstract: The invention provides a novel polymorph of Regadenoson. More particularly, the invention provides propylene glycol solvate of Regadenoson. The invention also provides a process for the preparation of propylene glycol solvate of Regadenoson.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 28, 2016
    Inventors: Jagadeesh Babu RANGISETTY, Manik Reddy PULLAGURLA, Mecheril Valsan NANDAKUMAR, Dokula Neelam NAIDU
  • An Improved Process for the Synthesis of Melphalan and the Hydrochloride Salt
    Publication number: 20160016889
    Abstract: The present invention relates to an improved process for the preparation of Melphalan, more specifically the invention relates to an efficient process for the preparation of substantially pure Melphalan hydrochloride (I).
    Type: Application
    Filed: March 4, 2014
    Publication date: January 21, 2016
    Inventors: Manik Reddy PULLAGURLA, Jagadeesh Babu RANGISETTY, Mecheril Valsan NANDAKUMAR, Madhava Reddy VEDURURI, Sreenu SAMIREDDI
  • Novel Process for the Preparation of (1-pyrazole-4-yl)-N-methylcarboxamide
    Publication number: 20150353593
    Abstract: The present invention relates to a novel process for the preparation of (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-6-aminopurin-2-yl}pyrazole-4-yl)-N-methylcarboxamide.
    Type: Application
    Filed: October 28, 2013
    Publication date: December 10, 2015
    Inventors: Manik Reddy PULLAGURLA, Jagadeesh Babu RANGISETTY, Mecheril Valsan NANDAKUMAR
  • Process for the Synthesis of Etravirine and Its Intermediates
    Publication number: 20150336900
    Abstract: The invention discloses the synthesis of Etravirine via intermediate 4-((4-amino-5-bromo-6-chloropyrimidin-2-yl) amino)benzonitrile and process for the preparation of Etravirine of the formula-I.
    Type: Application
    Filed: October 28, 2013
    Publication date: November 26, 2015
    Applicant: Biophore India Pharmaceuticals PVT. Ltd.
    Inventors: Manik Reddy PULLAGURLA, Jagadeesh Babu RANGISETTY, Mecheril Valsan NANDAKUMAR
  • Process for the Synthesis of Dabigatran and Its Intermediates
    Publication number: 20150246900
    Abstract: The present invention describes an improved process for the preparation of Dabigatran Etexilate (Formula-I), a pharmaceutically acceptable salt for the treatment of thromboses, cardiovascular diseases etc. and intermediates involved in the synthesis.
    Type: Application
    Filed: October 28, 2013
    Publication date: September 3, 2015
    Applicant: Biophore India Pharmeuticals PVT. Ltd.
    Inventors: Manik Reddy Pullagurla, Jagadeesh Babu Rangisetty, Mecheril Valsan Nandakumar