Patents by Inventor Megan McCAIN

Megan McCAIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUIDIC DEVICE FOR LONG-TERM EXPLANT CULTURE AND IMAGING
    Publication number: 20230250379
    Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.
    Type: Application
    Filed: March 22, 2023
    Publication date: August 10, 2023
    Applicants: University of Southern California, Children's Hospital Los Angeles
    Inventors: MEGAN McCAIN, JOYCELYN YIP, CHING-LING LIEN, MICHAEL HARRISON
  • Fluidic device for long-term explant culture and imaging
    Patent number: 11629320
    Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: April 18, 2023
    Assignees: University of Southern California, Children's Hospital Los Angeles
    Inventors: Megan McCain, Joycelyn Yip, Ching-Ling Lien, Michael Harrison
  • FLUIDIC DEVICE FOR LONG-TERM EXPLANT CULTURE AND IMAGING
    Publication number: 20200123488
    Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts.
    Type: Application
    Filed: October 16, 2019
    Publication date: April 23, 2020
    Inventors: Megan McCAIN, JOYCELYN YIP, CHING-LING LIEN, MICHAEL HARRISON