Patents by Inventor Megan N. Hersh

Megan N. Hersh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3?-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
    Patent number: 11001886
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: May 11, 2021
    Assignee: Agilent Technologies, Inc.
    Inventors: Brian P. Stupi, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20190127790
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Application
    Filed: June 27, 2018
    Publication date: May 2, 2019
    Inventors: Brian P. STUPI, Hong LI, Weidong WU, Megan N. HERSH, David HERTZOG, Sidney E. MORRIS, Michael L. METZKER
  • 3?-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
    Patent number: 10041115
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: August 7, 2018
    Assignee: LASERGEN, INC.
    Inventors: Brian P. Stupi, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20170327886
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 16, 2017
    Applicant: LASERGEN, INC.
    Inventors: Brian P. STUPI, Hong LI, Weidong WU, Megan N. HERSH, David HERTZOG, Sidney E. MORRIS, Michael L. METZKER
  • 3?-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
    Patent number: 9689035
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: June 27, 2017
    Assignee: LASERGEN, INC.
    Inventors: Brian P. Stupi, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20160369336
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Application
    Filed: June 21, 2016
    Publication date: December 22, 2016
    Applicant: LASERGEN, INC.
    Inventors: Brian P. STUPI, Hong LI, Weidong WU, Megan N. HERSH, David HERTZOG, Sidney E. MORRIS, Michael L. METZKER
  • 3?-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
    Patent number: 9399798
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: July 26, 2016
    Assignee: LASERGEN, INC.
    Inventors: Brian P. Stupi, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • Nucleotides and nucleosides and methods for their use in DNA sequencing
    Patent number: 9200319
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: December 1, 2015
    Assignee: Lasergen, Inc.
    Inventors: Vladislav A. Litosh, Megan N. Hersh, Brian P. Stupi, Weidong Wu, Michael L. Metzker
  • 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20150176074
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Application
    Filed: October 1, 2014
    Publication date: June 25, 2015
    Applicant: LASERGEN, INC.
    Inventors: Brian P. STUPI, Hong LI, Weidong WU, Megan N. HERSH, David HERTZOG, Sidney E. MORRIS, Michael L. METZKER
  • NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING
    Publication number: 20150140559
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Application
    Filed: October 21, 2014
    Publication date: May 21, 2015
    Applicant: LASERGEN, INC.
    Inventors: Vladislav A. LITOSH, Megan N. HERSH, Brian P. STUPI, Weidong WU, Michael L. METZKER
  • 3?-OH unblocked, fast photocleavable terminating nucleotides and methods for nucleic acid sequencing
    Patent number: 8889860
    Abstract: The present invention relates generally to 3?-OH unblocked, labeled and unlabeled nucleotides and nucleosides with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds, which may be represented by the following formulas: wherein the variables are defined herein, may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: November 18, 2014
    Assignee: Lasergen, Inc.
    Inventors: Brian Stupi, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • Nucleotides and nucleosides and methods for their use in DNA sequencing
    Patent number: 8877905
    Abstract: The present invention relates generally to labeled and unlabeled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: November 4, 2014
    Assignee: LaserGen, Inc.
    Inventors: Vladislav A. Litosh, Megan N. Hersh, Brian P. Stupi, Weidong Wu, Michael L. Metzker
  • NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING
    Publication number: 20140051848
    Abstract: The present invention relates generally to labeled and unlabeled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Application
    Filed: June 27, 2013
    Publication date: February 20, 2014
    Inventors: Vladislav A. LITOSH, Megan N. HERSH, Brian P. STUPI, Weidong WU, Michael L. METZKER
  • Nucleotides and nucleosides and methods for their use in DNA sequencing
    Patent number: 8497360
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 30, 2013
    Assignee: LaserGen, Inc.
    Inventors: Vladislav A. Litosh, Megan N. Hersh, Brian P. Stupi, Weidong Wu, Michael L. Metzker
  • 3'-OH UNBLOCKED, FAST PHOTOCLEAVABLE TERMINATING NUCLEOTIDES AND METHODS FOR NUCLEIC ACID SEQUENCING
    Publication number: 20130122489
    Abstract: The present invention relates generally to 3?-OH unblocked nucleotides and nucleosides labeled and unlabeled with 5-methoxy-substituted nitrobenzyl-based photocleavable terminating groups for use in methods and systems related to DNA and RNA sequencing and analysis. These compounds may be used as reversible terminators as they exhibit fast nucleotide incorporation kinetics, single-base termination, high nucleotide selectivity, and rapid terminating group cleavage that results in a naturally occurring nucleotide.
    Type: Application
    Filed: September 13, 2012
    Publication date: May 16, 2013
    Inventors: Brian STUPI, Hong Li, Weidong Wu, Megan N. Hersh, David Hertzog, Sidney E. Morris, Michael L. Metzker
  • Nucleotides and Nucleosides and Methods for their Use in DNA Sequencing
    Publication number: 20130035237
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Application
    Filed: February 28, 2012
    Publication date: February 7, 2013
    Inventors: Vladislav A. Litosh, Megan N. Hersh, Brian P. Stupi, Weidong Wu, Michael L. Metzker
  • Nucleotides and nucleosides and methods for their use in DNA sequencing
    Patent number: 8148503
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: April 3, 2012
    Assignee: Lasergen, Inc.
    Inventors: Vladislav A. Litosh, Megan N. Hersh, Brian P. Stupi, Weidong Wu, Michael L. Metzker
  • NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING
    Publication number: 20100041041
    Abstract: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA sequencing and its application in biomedical research.
    Type: Application
    Filed: June 11, 2009
    Publication date: February 18, 2010
    Inventors: Vladislav A. LITOSH, Megan N. HERSH, Brian P. STUPI, Weidong WU, Michael L. METZKER