Patents by Inventor Megan S. Keiser

Megan S. Keiser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINED TRANSGENE AND INTRON-DERIVED MIRNA THERAPY FOR TREATMENT OF SCA1
    Publication number: 20220288101
    Abstract: Provided herein are nucleic acids that comprise both an expression cassette for a therapeutic protein (e.g., Ataxin-1-like) and an expression cassette for a therapeutic inhibitory RNA (e.g., a miRNA that targets ataxin-1 mRNA). In some instances, the expression cassette for the therapeutic inhibitor RNA lies within an intron of the expression cassette for the therapeutic protein. Also provided are methods of using the nucleic acids to treat spinocerebellar.
    Type: Application
    Filed: August 14, 2020
    Publication date: September 15, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Beverly L. DAVIDSON, Ellie CARRELL, Alejandro Mas MONTEYS, Megan S. KEISER
  • Therapeutic for treatment of diseases including the central nervous system
    Patent number: 11155817
    Abstract: The present disclosure provides filler or stuffer sequences, compositions thereof including expression cassettes and vectors, such as viral (e.g., AAV) vectors and methods of delivering a therapeutic agent to a mammal and/or treating a disease.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: October 26, 2021
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Beverly L. Davidson, Alejandro Mas Monteys, Megan S. Keiser
  • Methods of delivery of transgenes for treating brain diseases
    Patent number: 11027024
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant adeno-associated virus (rAAV) particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding a therapeutic agent inserted between a pair of AAV inverted terminal repeats in a manner effective to infect the CNS cell of the non-rodent mammal such that the CNS cell expresses the therapeutic agent in the non-rodent mammal.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: June 8, 2021
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Megan S. Keiser
  • THERAPEUTIC FOR TREATMENT OF DISEASES INCLUDING THE CENTRAL NERVOUS SYSTEM
    Publication number: 20190071671
    Abstract: The present disclosure provides filler or stuffer sequences, compositions thereof including expression cassettes and vectors, such as viral (e.g., AAV) vectors and methods of delivering a therapeutic agent to a mammal and/or treating a disease.
    Type: Application
    Filed: March 17, 2017
    Publication date: March 7, 2019
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Beverly L. DAVIDSON, Alejandro Mas MONTEYS, Megan S. KEISER
  • METHODS OF DELIVERY OF TRANSGENES FOR TREATING BRAIN DISEASES
    Publication number: 20180169269
    Abstract: The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's deep cerebella nuclei a recombinant adeno-associated virus (rAAV) particle comprising an AAV capsid protein and a vector comprising a nucleic acid encoding a therapeutic agent inserted between a pair of AAV inverted terminal repeats in a manner effective to infect the CNS cell of the non-rodent mammal such that the CNS cell expresses the therapeutic agent in the non-rodent mammal.
    Type: Application
    Filed: May 31, 2016
    Publication date: June 21, 2018
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Beverly L. Davidson, Megan S. Keiser