Abstract: Embodiments of the disclosure include methods and compositions for the treatment of neovascularization- and ischemic retinopathy-related disorders. In some embodiments, a composition comprising an effective amount of an apoA-I binding protein or its agonist in combination with anti-VEGF reagents is administered to an individual in need thereof to treat, prevent, reverse, and/or meliorate conditions associated with macular degeneration or cancer. In some embodiments, a composition comprising an effective mount of an AIBP-inhibitor is administered to an individual in need thereof to stimulate revascularization in the eye to treat, prevent, reverse, and/or ameliorate conditions associated with ischemic retinopathies.