Patents by Inventor Megan Sykes

Megan Sykes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INDUCING TOLERANCE
    Publication number: 20120269806
    Abstract: Methods of inducing tolerance, and promoting graft acceptance, are described herein. The methods include administering to a recipient hematopoietic stem cells and an agonist of Programmed Death 1 (PD-1).
    Type: Application
    Filed: August 21, 2008
    Publication date: October 25, 2012
    Applicant: The General Hospital Corporation
    Inventor: Megan A. Sykes
  • Methods for Inducing Mixed Chimerism
    Publication number: 20120100160
    Abstract: Fusion protein-siRNA complexes that specifically target activated T cells, and methods of use thereof, are described.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 26, 2012
    Applicants: IMMUNE DISEASE INSTITUTE, THE GENERAL HOSPITAL CORPORATION
    Inventors: Carrie Lucas, Megan Sykes, Judy Lieberman, Ann Schlesinger, Motomu Shimaoka
  • Methods for human allografting
    Patent number: 7939062
    Abstract: A method of preparing a human recipient for a graft from a human which includes: administering donor peripheral blood progenitor cells to the recipient, and providing a minimally ablative.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: May 10, 2011
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Treatment of hematologic disorders
    Patent number: 7892578
    Abstract: The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: February 22, 2011
    Assignee: The General Hospital Corporation
    Inventors: Megan Sykes, Thomas R. Spitzer
  • METHODS FOR HUMAN ALLOGRAFTING
    Publication number: 20100074902
    Abstract: A method of preparing a human recipient for a graft from a human which includes: administering donor peripheral blood progenitor cells to the recipient, and providing a minimally ablative.
    Type: Application
    Filed: November 30, 2009
    Publication date: March 25, 2010
    Applicant: The General Hospital Corporation
    Inventor: Megan Sykes
  • Methods for human allografting
    Patent number: 7638121
    Abstract: A method of preparing a human recipient for a graft from a human which includes: administering donor peripheral blood progenitor cells to the recipient, and providing a minimally ablative.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: December 29, 2009
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Blockade of T cell migration into epithelial GVHD target tissues as an approach to achieving anti-tumor effects against lymphohematopoietic malignancies without GVHD
    Patent number: 7498023
    Abstract: Antagonists of T cell migration are used to reduce GVHD in recipients of hematopoietic cell grafts. The administration of antagonists of T cell migration can be used in combination with conventional methods of bone marrow transplantation and in combination with the administration of donor leukocytes.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: March 3, 2009
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Treatment of Hematologic Disorders
    Publication number: 20090028870
    Abstract: The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
    Type: Application
    Filed: August 4, 2008
    Publication date: January 29, 2009
    Inventors: Megan Sykes, Thomas R. Spitzer
  • Kits for treatment of hematologic disorders
    Patent number: 7408039
    Abstract: The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: August 5, 2008
    Assignee: The General Hospital Corporation
    Inventors: Megan Sykes, Thomas R. Spitzer
  • METHODS FOR HUMAN ALLOGRAFTING
    Publication number: 20080175850
    Abstract: A method of preparing a human recipient for a graft from a human which includes: administering donor peripheral blood progenitor cells to the recipient, and providing a minimally ablative.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 24, 2008
    Inventor: Megan Sykes
  • Methods for human allografting
    Patent number: 7332157
    Abstract: A method of preparing a human recipient for a graft from a human which includes: inducing mixed chimerism in the recipient (e.g., by administering to the recipient irradiation or chemotherapy), administering thymic irradiation, administering an antibody that depletes T cells, administering donor hematopoietic progenitor cells to the recipient, and administering an immunosuppressant.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: February 19, 2008
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Methods and compositions for inhibition of immune responses
    Publication number: 20070113297
    Abstract: Methods and compositions for modulating immune responses are provided herein.
    Type: Application
    Filed: September 12, 2006
    Publication date: May 17, 2007
    Inventors: Yongguang Yang, Megan Sykes
  • Mixed chimerism and tolerance
    Patent number: 6877514
    Abstract: A method of inducing tolerance without whole body irradiation.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: April 12, 2005
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Mixed chimerism and tolerance
    Publication number: 20040247579
    Abstract: A method of inducing tolerance without whole body irradiation.
    Type: Application
    Filed: October 29, 2003
    Publication date: December 9, 2004
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventor: Megan Sykes
  • Mixed chimerism and tolerance
    Patent number: 6718986
    Abstract: A method of inducing tolerance without whole body irradiation.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: April 13, 2004
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes
  • Blockade of T cell migration into epithelial GVHD target tissues as an approach to achieving anti-tumor effects against lymphohematopoietic malignancies without GVHD
    Publication number: 20040067220
    Abstract: Antagonists of T cell migration are used to reduce GVHD in recipients of hematopoietic cell grafts. The administration of antagonists of T cell migration can be used in combination with conventional methods of bone marrow transplantation and in combination with the administration of donor leukocytes.
    Type: Application
    Filed: May 14, 2003
    Publication date: April 8, 2004
    Applicant: The General Hospital Corporation
    Inventor: Megan Sykes
  • Treatment of hematologic disorders
    Publication number: 20030157077
    Abstract: The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
    Type: Application
    Filed: February 25, 2003
    Publication date: August 21, 2003
    Inventors: Megan Sykes, Thomas R. Spitzer
  • Treatment of hematologic disorders
    Patent number: 6558662
    Abstract: The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: May 6, 2003
    Assignee: The General Hospital Corporation
    Inventors: Megan Sykes, Thomas R. Spitzer
  • Mixed chimerism and tolerance
    Publication number: 20030075187
    Abstract: A method of inducing tolerance without whole body irradiation.
    Type: Application
    Filed: May 24, 2002
    Publication date: April 24, 2003
    Applicant: The General Hospital Corporation
    Inventor: Megan Sykes
  • Costimulatory blockade and mixed chimerism in transplantation
    Patent number: 6514513
    Abstract: Use of blockade of costimulation and hematopoietic stem cell transplantation in the promotion of graft acceptance.
    Type: Grant
    Filed: February 4, 1999
    Date of Patent: February 4, 2003
    Assignee: The General Hospital Corporation
    Inventor: Megan Sykes