Patents by Inventor Megan van Overbeek

Megan van Overbeek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for using DNA repair for cell engineering
    Patent number: 11155814
    Abstract: Methods for gene editing and predicting non-random editing events are described. The methods use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems to characterize and manipulate DNA repair outcomes at Cas-initiated double-strand breaks (DSBs) to anticipate functional outcomes.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: October 26, 2021
    Assignee: Caribou Biosciences, Inc.
    Inventors: Daniel Capurso, Andrew P. May, Megan Van Overbeek
  • PROTEIN ENGINEERING METHODS
    Publication number: 20190264193
    Abstract: Methods for preparing DNA libraries for protein engineering are described. The methods use programmable nucleases, such as from Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems, to generate diverse protein engineering libraries.
    Type: Application
    Filed: August 11, 2017
    Publication date: August 29, 2019
    Applicant: Caribou Biosciences, Inc.
    Inventors: Shawdee Eshghi, Elizabeth Garner, Andrew P. May, Megan Van Overbeek, Euan M. Slorach, Katharina Friederike Sonja Stengel
  • METHODS FOR USING DNA REPAIR FOR CELL ENGINEERING (as amended)
    Publication number: 20190055549
    Abstract: Methods for gene editing and predicting non-random editing events are described. The methods use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems to characterize and manipulate DNA repair outcomes at Cas-initiated double-strand breaks (DSBs) to anticipate functional outcomes.
    Type: Application
    Filed: February 21, 2017
    Publication date: February 21, 2019
    Inventors: Daniel Capurso, Andrew P. May, Megan Van Overbeek
  • METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY
    Publication number: 20180171360
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek
  • Methods for increasing CAS9-mediated engineering efficiency
    Patent number: 9970030
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: May 15, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek
  • DIRECTED NUCLEIC ACID REPAIR
    Publication number: 20170058272
    Abstract: The present disclosure provides compositions and methods for enhancing directed nucleic acid repair, which are useful in the area of genome engineering.
    Type: Application
    Filed: August 31, 2016
    Publication date: March 2, 2017
    Inventors: Matthew M. Carter, Megan Van Overbeek, Andrew Paul May
  • METHODS FOR INCREASING CAS9-MEDIATED ENGINEERING EFFICIENCY
    Publication number: 20160257973
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Application
    Filed: August 26, 2015
    Publication date: September 8, 2016
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek