Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: A massager device providing multiple massaging effects with thermal enhancement is disclosed. The device comprises a cylindrical body with a first end which is closed and a second end which is open, a first cap coupled to the first end, and a second cap coupled to the second end, an assembly of DC vibrator embedded in the first end, and a switch embedded in the first cap. The cylindrical body comprises an inner layer and an outer layer. The inner layer is made of ABS materials. The outer layer is made of silicone rubber and comprises a base sheet and an array of evenly spaced identical elastic nipples positioned outwardly with their bottoms embedded in the base sheet. The first cap and the second cap have substantially identical exterior shape and size, each of which having an inner layer made of ABS materials and a silicone rubber ring coupled to the inner layer's exterior. The hollow space made by the cylindrical body and the second cap may contain thermal media such as water or gel.

Abstract: A massager device providing multiple massaging effects with thermal enhancement is disclosed. The device comprises a cylindrical body with a first end which is closed and a second end which is open, a first cap coupled to the first end, and a second cap coupled to the second end, an assembly of DC vibrator embedded in the first end, and a switch embedded in the first cap. The cylindrical body comprises an inner layer and an outer layer. The inner layer is made of ABS materials. The outer layer is made of silicone rubber and comprises a base sheet and an array of evenly spaced identical elastic nipples positioned outwardly with their bottoms embedded in the base sheet. The first cap and the second cap have substantially identical exterior shape and size, each of which having an inner layer made of ABS materials and a silicone rubber ring coupled to the inner layer's exterior. The hollow space made by the cylindrical body and the second cap may contain thermal media such as water or gel.